Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China
Background/Aim: Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chi...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders extra 2014-11, Vol.4 (3), p.450-456 |
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| container_title | Dementia and geriatric cognitive disorders extra |
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| creator | Liu, Mengyuan Zhang, Ying Huo, Ya Ruth Liu, Shuling Liu, Shuai Wang, Junwei Wang, Change Wang, Jinhuan Ji, Yong |
| description | Background/Aim: Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chinese patients with mild-to-moderate AD. Methods: In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination. Results: No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two. Conclusions: Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD. |
| doi_str_mv | 10.1159/000367596 |
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We investigated this association in Chinese patients with mild-to-moderate AD. Methods: In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination. Results: No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two. Conclusions: Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD.</description><identifier>ISSN: 1664-5464</identifier><identifier>EISSN: 1664-5464</identifier><identifier>DOI: 10.1159/000367596</identifier><identifier>PMID: 25538729</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Alzheimer's disease ; APOE ; Chinese population ; CYP2D6 ; Donepezil ; Original ; Original Research Article ; Polymorphism</subject><ispartof>Dementia and geriatric cognitive disorders extra, 2014-11, Vol.4 (3), p.450-456</ispartof><rights>2014 S. Karger AG, Basel</rights><rights>Copyright © 2014 by S. Karger AG, Basel 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-60f2d5195aade427a4242c3351dba9a65ab205e6524989a8153a6b0f659436e53</citedby><cites>FETCH-LOGICAL-c420t-60f2d5195aade427a4242c3351dba9a65ab205e6524989a8153a6b0f659436e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264516/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264516/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,27644,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25538729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Mengyuan</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Huo, Ya Ruth</creatorcontrib><creatorcontrib>Liu, Shuling</creatorcontrib><creatorcontrib>Liu, Shuai</creatorcontrib><creatorcontrib>Wang, Junwei</creatorcontrib><creatorcontrib>Wang, Change</creatorcontrib><creatorcontrib>Wang, Jinhuan</creatorcontrib><creatorcontrib>Ji, Yong</creatorcontrib><title>Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China</title><title>Dementia and geriatric cognitive disorders extra</title><addtitle>Dement Geriatr Cogn Disord Extra</addtitle><description>Background/Aim: Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chinese patients with mild-to-moderate AD. Methods: In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination. Results: No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two. Conclusions: Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD.</description><subject>Alzheimer's disease</subject><subject>APOE</subject><subject>Chinese population</subject><subject>CYP2D6</subject><subject>Donepezil</subject><subject>Original</subject><subject>Original Research Article</subject><subject>Polymorphism</subject><issn>1664-5464</issn><issn>1664-5464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkkFv0zAUxyMEYtPYgTtCljjADgXbsd34glS13ag0sQrGgZP1mrw0Hokd7BS0fTG-Ht7aVRviZMv--fe3n1-WvWT0PWNSf6CU5mostXqSHTKlxEgKJZ4-mB9kxzFeJYxKqYUWz7MDLmVejLk-zP4sXN1u0JVIfE2GBkmIjBZUF5J8tW7dIvm8KVv0g62QLH173fnQNzZ29_z0-5LPFDlDhwRcRSbLi_k_oLsDv2DsvYtIBk9m3mGPN7YllwFh6NANxDqyhMGmaSS_7dCQSXvToO0wvI1kZiNCOpugaWMdvMie1dBGPN6NR9m30_nl9NPo_OJsMZ2cj0rB6TBStOaVZFoCVCj4GAQXvMxzyaoVaFASVpxKVJILXWgomMxBrWitUqVyhTI_yhZbb-XhyvTBdhCujQdr7hZ8WBsIg00VMroqkXItKTIlqpoDSFqwOoXJsc5pnVwft65-s-ow0W4I0D6SPt5xtjFr_8sIroRkKgne7QTB_9xgHExnY4ltCw79JpqUS0X6OyESerJFy-BjDFjvYxg1t31j9n2T2NcP77Un77skAW-2wA8Iawx7YDafbxWmr26f9-q_1C7lL5ry0gU</recordid><startdate>20141115</startdate><enddate>20141115</enddate><creator>Liu, Mengyuan</creator><creator>Zhang, Ying</creator><creator>Huo, Ya Ruth</creator><creator>Liu, Shuling</creator><creator>Liu, Shuai</creator><creator>Wang, Junwei</creator><creator>Wang, Change</creator><creator>Wang, Jinhuan</creator><creator>Ji, Yong</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141115</creationdate><title>Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China</title><author>Liu, Mengyuan ; Zhang, Ying ; Huo, Ya Ruth ; Liu, Shuling ; Liu, Shuai ; Wang, Junwei ; Wang, Change ; Wang, Jinhuan ; Ji, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-60f2d5195aade427a4242c3351dba9a65ab205e6524989a8153a6b0f659436e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alzheimer's disease</topic><topic>APOE</topic><topic>Chinese population</topic><topic>CYP2D6</topic><topic>Donepezil</topic><topic>Original</topic><topic>Original Research Article</topic><topic>Polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Mengyuan</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Huo, Ya Ruth</creatorcontrib><creatorcontrib>Liu, Shuling</creatorcontrib><creatorcontrib>Liu, Shuai</creatorcontrib><creatorcontrib>Wang, Junwei</creatorcontrib><creatorcontrib>Wang, Change</creatorcontrib><creatorcontrib>Wang, Jinhuan</creatorcontrib><creatorcontrib>Ji, Yong</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Dementia and geriatric cognitive disorders extra</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Mengyuan</au><au>Zhang, Ying</au><au>Huo, Ya Ruth</au><au>Liu, Shuling</au><au>Liu, Shuai</au><au>Wang, Junwei</au><au>Wang, Change</au><au>Wang, Jinhuan</au><au>Ji, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China</atitle><jtitle>Dementia and geriatric cognitive disorders extra</jtitle><addtitle>Dement Geriatr Cogn Disord Extra</addtitle><date>2014-11-15</date><risdate>2014</risdate><volume>4</volume><issue>3</issue><spage>450</spage><epage>456</epage><pages>450-456</pages><issn>1664-5464</issn><eissn>1664-5464</eissn><abstract>Background/Aim: Recent data have indicated that the rs1080985 single nucleotide polymorphism (SNP) of the cytochrome P450 (CYP) 2D6 and the common apolipoprotein E (APOE) gene may affect the response to donepezil in patients with Alzheimer's disease (AD). We investigated this association in Chinese patients with mild-to-moderate AD. Methods: In this prospective cohort study, analyses of CYP2D6 and APOE were conducted in 208 native Chinese patients with mild-to-moderate AD. All patients were treated with donepezil 5 mg/day for 6 months, and the response to treatment was assessed using the Mini-Mental State Examination. Results: No significant differences between responders (68.9%) and nonresponders (31.1%) to donepezil treatment (6 months' duration) were observed in the distribution of the CYP2D6 rs1080985 SNP, common APOE polymorphism or a combination of the two. Conclusions: Our results suggest that neither the CYP2D6 nor the APOE polymorphism influences the 6-month response to donepezil treatment in a Chinese population with AD.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>25538729</pmid><doi>10.1159/000367596</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer's disease APOE Chinese population CYP2D6 Donepezil Original Original Research Article Polymorphism |
| title | Influence of the rs1080985 Single Nucleotide Polymorphism of the CYP2D6 Gene and APOE Polymorphism on the Response to Donepezil Treatment in Patients with Alzheimer's Disease in China |
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