The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR). How a small molecule extends C. elegans lifespan Calo...

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Veröffentlicht in:	Nature (London) 2014-06, Vol.510 (7505), p.397-401
Hauptverfasser:	Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 14/19 14/35 631/208 631/45 631/92 64/11 82/29 82/58 96/1 Adenosine triphosphate Animals Caenorhabditis elegans Caenorhabditis elegans - drug effects Cell Line Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Gene Knockdown Techniques Genetic aspects HEK293 Cells Humanities and Social Sciences Humans Jurkat Cells Ketoglutaric Acids - pharmacology letter Life spans (Biology) Longevity - drug effects Longevity - genetics Longevity - physiology Metabolites Mice Mitochondrial Proton-Translocating ATPases - genetics Mitochondrial Proton-Translocating ATPases - metabolism multidisciplinary Properties Protein Binding Science TOR Serine-Threonine Kinases - metabolism
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