Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription facto...

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Veröffentlicht in:	Nature communications 2014-11, Vol.5 (1), p.5323-5323, Article 5323
Hauptverfasser:	Puvvula, Pavan Kumar, Desetty, Rohini Devi, Pineau, Pascal, Marchio, Agnés, Moon, Anne, Dejean, Anne, Bischof, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/2568 631/80/509 CCAAT-Binding Factor CCAAT-Binding Factor - genetics CCAAT-Binding Factor - metabolism Cell Cycle Checkpoints Cell Cycle Checkpoints - genetics Cell Cycle Proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cellular Senescence Cellular Senescence - genetics E2F Transcription Factors E2F Transcription Factors - genetics E2F Transcription Factors - metabolism Fibroblasts Fibroblasts - metabolism Heterogeneous-Nuclear Ribonucleoprotein U Heterogeneous-Nuclear Ribonucleoprotein U - genetics Heterogeneous-Nuclear Ribonucleoprotein U - metabolism Humanities and Social Sciences Humans Life Sciences multidisciplinary Polycomb Repressive Complex 2 Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism RNA, Long Noncoding RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Science Science (multidisciplinary)
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