Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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Veröffentlicht in:	Nature communications 2014-11, Vol.5 (1), p.5514-5514, Article 5514
Hauptverfasser:	Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 631/378/1689/1602 631/80/86 692/308 692/420 Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy - genetics Bone Marrow Cells - cytology Carrier Proteins - genetics Cell Line Enzymes Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - metabolism Intracellular Signaling Peptides and Proteins Kinases Laboratory animals Male Medicine Membrane Glycoproteins - genetics Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mice Mice, Inbred BALB C Mice, SCID Mice, Transgenic Microspheres multidisciplinary Niemann-Pick Disease, Type C - genetics Pathogenesis Phthalazines - pharmacology Physiology Protein Kinase Inhibitors - pharmacology Purkinje Cells - metabolism Pyridines - pharmacology RNA Interference RNA, Small Interfering Science Science (multidisciplinary) Sphingosine Stem cells Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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