Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice
The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ11...
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| Veröffentlicht in: | Microbes and Environments 2014, Vol.29(4), pp.427-430 |
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| creator | Kameyama, Keishi Itoh, Kikuji |
| description | The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity. |
| doi_str_mv | 10.1264/jsme2.ME14054 |
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We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.</description><identifier>ISSN: 1342-6311</identifier><identifier>EISSN: 1347-4405</identifier><identifier>DOI: 10.1264/jsme2.ME14054</identifier><identifier>PMID: 25283478</identifier><language>eng</language><publisher>Japan: Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles</publisher><subject>Animals ; Bacteria ; Blood Glucose - analysis ; Clostridiales - growth & development ; diabetes ; Diabetes Mellitus - microbiology ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Feces - microbiology ; Gastrointestinal Tract - microbiology ; gnotobiotic mouse ; Gram-Positive Bacterial Infections - complications ; gut microbiota ; Insulin - blood ; Lachnospiraceae ; Liver - pathology ; Mesentery - pathology ; Mice, Obese ; Molecular Sequence Data ; Sequence Analysis, DNA ; Short Communication ; T-RFLP</subject><ispartof>Microbes and Environments, 2014, Vol.29(4), pp.427-430</ispartof><rights>2014 by Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology</rights><rights>Copyright Japan Science and Technology Agency 2014</rights><rights>Copyright 2014 by Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-7abd574a15678ba8adabf47af2f0c9abc6d9448679378fc99a1a252f74ba88b03</citedby><cites>FETCH-LOGICAL-c702t-7abd574a15678ba8adabf47af2f0c9abc6d9448679378fc99a1a252f74ba88b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262368/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262368/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25283478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kameyama, Keishi</creatorcontrib><creatorcontrib>Itoh, Kikuji</creatorcontrib><title>Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice</title><title>Microbes and Environments</title><addtitle>Microbes Environ.</addtitle><description>The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Blood Glucose - analysis</subject><subject>Clostridiales - growth & development</subject><subject>diabetes</subject><subject>Diabetes Mellitus - microbiology</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Feces - microbiology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>gnotobiotic mouse</subject><subject>Gram-Positive Bacterial Infections - complications</subject><subject>gut microbiota</subject><subject>Insulin - blood</subject><subject>Lachnospiraceae</subject><subject>Liver - pathology</subject><subject>Mesentery - pathology</subject><subject>Mice, Obese</subject><subject>Molecular Sequence Data</subject><subject>Sequence Analysis, DNA</subject><subject>Short Communication</subject><subject>T-RFLP</subject><issn>1342-6311</issn><issn>1347-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFvEzEQhS0EoiVw5IosceGyZdfrtb0XJJoWqJSqFzhbY2e2cbRrB9tbqfx6nCZEwMX26H1-mplHyNumvmiY4B-3aUJ2cXvd8Lrjz8h503JZ8VI8f3qzSrRNc0ZepbSt67btJHtJzljHVOHUOQk3PmPKzsNIl2EM3v2C7IKn5pECXYHd-JB2LoJFQHoJNmN081RYn6Mzc_lMc6B5g_QKH3AMuwl9pmGgVw4M7mXn6Z3BhPTWWXxNXgwwJnxzvBfkx5fr78tv1eru683y86qysma5kmDWneTQdEIqAwrWYAYuYWBDbXswVqx7zpWQfSvVYPseGihDDZIXWJm6XZBPB9_dbCZc29JUhFHvopsgPuoATv-reLfR9-FBcyZYK1Qx-HA0iOHnXFakJ5csjiN4DHPSjep6LkXHRUHf_4duwxzLRgslO8GY6srmF6Q6UDaGlCIOp2aaWu-j1E9R6mOUhX_39wQn-k92BVgegG3KcI8nAGJ2dsSjHes13x9H25NqNxA1-vY3P3a00Q</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kameyama, Keishi</creator><creator>Itoh, Kikuji</creator><general>Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Microbial Ecology (JSME)/The Japanese Society of Soil Microbiology (JSSM)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>2014</creationdate><title>Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice</title><author>Kameyama, Keishi ; 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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Animals Bacteria Blood Glucose - analysis Clostridiales - growth & development diabetes Diabetes Mellitus - microbiology DNA, Bacterial - chemistry DNA, Bacterial - genetics Feces - microbiology Gastrointestinal Tract - microbiology gnotobiotic mouse Gram-Positive Bacterial Infections - complications gut microbiota Insulin - blood Lachnospiraceae Liver - pathology Mesentery - pathology Mice, Obese Molecular Sequence Data Sequence Analysis, DNA Short Communication T-RFLP |
| title | Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice |
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