A 12 week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV-infected Zambians initiating antiretroviral therapy

Undernourished, HIV-infected adults in sub-Saharan Africa have high levels of systemic inflammation, which is a risk factor for mortality and other adverse health outcomes. We hypothesized that microbial translocation, due to the deleterious effects of HIV and poor nutrition on intestinal defenses a...

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Veröffentlicht in:	BMC infectious diseases 2014-09, Vol.14 (1), p.521-521, Article 521
Hauptverfasser:	Canipe, Ashley, Chidumayo, Takondwa, Blevins, Meridith, Bestawros, Michael, Bala, Jay, Kelly, Paul, Filteau, Suzanne, Shepherd, Bryan E, Heimburger, Douglas C, Koethe, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins Adult Analysis Anti-HIV Agents - therapeutic use Bacterial Translocation Biomarkers Biomarkers - blood Biomedical research Body mass index C-Reactive Protein - metabolism Carrier Proteins - blood Clinical trials Developing countries Disease Disease susceptibility Drug therapy Female Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Health aspects Hepatology HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - microbiology Human immunodeficiency virus Humans Immunocompromised Host Infections Inflammation - blood Inflammation Mediators - blood LDCs Longitudinal Studies Male Malnutrition Malnutrition - immunology Malnutrition - virology Medical research Medicine Medicine, Experimental Membrane Glycoproteins - blood Mitogens Mortality Permeability Pilot Projects Revisions Risk Factors Studies Teaching hospitals Tumor Necrosis Factor-alpha - blood Urine Zambia
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