Mediators of asthma outcomes
Background Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. Objective National Institutes of Health institutes and other federal agenc...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2012-03, Vol.129 (3), p.S136-S141 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 129 |
| creator | Rand, Cynthia S., PhD Wright, Rosalind J., MD, MPH Cabana, Michael D., MD, MPH Foggs, Michael B., MD Halterman, Jill S., MD, MPH Olson, Lynn, PhD Vollmer, William M., PhD Wilson, Sandra R., PhD Taggart, Virginia, MPH |
| description | Background Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. Objective National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. Methods We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. Results The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. Conclusions Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions. |
| doi_str_mv | 10.1016/j.jaci.2011.12.987 |
| format | Article |
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Objective National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. Methods We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. Results The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. Conclusions Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2011.12.987</identifier><identifier>PMID: 22386506</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adherence ; Allergy and Immunology ; Asthma - psychology ; Asthma - therapy ; asthma patient education ; Behavior ; Biomarkers ; Biomedical Research - standards ; Children & youth ; Clinical trials ; Depression ; Humans ; Managerial skills ; Mental depression ; Mortality ; Patient Compliance ; Patient Education as Topic ; Postpartum period ; Quality of life ; Questionnaires ; Self Care ; self-management skills ; Stress ; Stress, Psychological ; Studies ; Treatment Outcome</subject><ispartof>Journal of allergy and clinical immunology, 2012-03, Vol.129 (3), p.S136-S141</ispartof><rights>2012</rights><rights>Published by Mosby, Inc.</rights><rights>Copyright Elsevier Limited Mar 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-a1b66d59d3d0e198c3dd9f4d6c2c2b07accff9f3ff9c8ce9896d421ea14805523</citedby><cites>FETCH-LOGICAL-c537t-a1b66d59d3d0e198c3dd9f4d6c2c2b07accff9f3ff9c8ce9896d421ea14805523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674911029563$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22386506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rand, Cynthia S., PhD</creatorcontrib><creatorcontrib>Wright, Rosalind J., MD, MPH</creatorcontrib><creatorcontrib>Cabana, Michael D., MD, MPH</creatorcontrib><creatorcontrib>Foggs, Michael B., MD</creatorcontrib><creatorcontrib>Halterman, Jill S., MD, MPH</creatorcontrib><creatorcontrib>Olson, Lynn, PhD</creatorcontrib><creatorcontrib>Vollmer, William M., PhD</creatorcontrib><creatorcontrib>Wilson, Sandra R., PhD</creatorcontrib><creatorcontrib>Taggart, Virginia, MPH</creatorcontrib><title>Mediators of asthma outcomes</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. Objective National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. Methods We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. Results The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. Conclusions Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.</description><subject>Adherence</subject><subject>Allergy and Immunology</subject><subject>Asthma - psychology</subject><subject>Asthma - therapy</subject><subject>asthma patient education</subject><subject>Behavior</subject><subject>Biomarkers</subject><subject>Biomedical Research - standards</subject><subject>Children & youth</subject><subject>Clinical trials</subject><subject>Depression</subject><subject>Humans</subject><subject>Managerial skills</subject><subject>Mental depression</subject><subject>Mortality</subject><subject>Patient Compliance</subject><subject>Patient Education as Topic</subject><subject>Postpartum period</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Self Care</subject><subject>self-management skills</subject><subject>Stress</subject><subject>Stress, Psychological</subject><subject>Studies</subject><subject>Treatment Outcome</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdFr1TAUxoM43N30HxCRCz741JqTtmkCMpDh3GDig_p8yD1JXWrbzKQd7L835c459-BLQsh3Ps73-xh7CbwEDvJdX_aGfCk4QAmi1Kp9wjbAdVtIJZqnbMO5hkK2tT5kRyn1PL8rpZ-xQyEqJRsuN-zVZ2e9mUNM29BtTZqvRrMNy0xhdOk5O-jMkNyLu_uYfT_7-O30vLj88uni9MNlQU3VzoWBnZS20bay3IFWVFmru9pKEiR2vDVEXae7Kh-kyGmlpa0FOAO14k0jqmN2sve9Xnajs-SmOZoBr6MfTbzFYDz--zP5K_wRbrAWEoRYDd7eGcTwa3FpxtEncsNgJheWhFq0WvMWICvfPFL2YYlTTofQ8FrVAPXqJ_YqiiGl6Lr7XYDjyh57XNnjyh5BYGafh14_THE_8gd2FrzfC1xmeeNdxETeTZQbiI5mtMH_3__k0TgNfvJkhp_u1qW_OTAJ5Ph1bX8tH4AL3ciq-g05FamJ</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Rand, Cynthia S., PhD</creator><creator>Wright, Rosalind J., MD, MPH</creator><creator>Cabana, Michael D., MD, MPH</creator><creator>Foggs, Michael B., MD</creator><creator>Halterman, Jill S., MD, MPH</creator><creator>Olson, Lynn, PhD</creator><creator>Vollmer, William M., PhD</creator><creator>Wilson, Sandra R., PhD</creator><creator>Taggart, Virginia, MPH</creator><general>Mosby, Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Mediators of asthma outcomes</title><author>Rand, Cynthia S., PhD ; Wright, Rosalind J., MD, MPH ; Cabana, Michael D., MD, MPH ; Foggs, Michael B., MD ; Halterman, Jill S., MD, MPH ; Olson, Lynn, PhD ; Vollmer, William M., PhD ; Wilson, Sandra R., PhD ; Taggart, Virginia, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-a1b66d59d3d0e198c3dd9f4d6c2c2b07accff9f3ff9c8ce9896d421ea14805523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adherence</topic><topic>Allergy and Immunology</topic><topic>Asthma - psychology</topic><topic>Asthma - therapy</topic><topic>asthma patient education</topic><topic>Behavior</topic><topic>Biomarkers</topic><topic>Biomedical Research - standards</topic><topic>Children & youth</topic><topic>Clinical trials</topic><topic>Depression</topic><topic>Humans</topic><topic>Managerial skills</topic><topic>Mental depression</topic><topic>Mortality</topic><topic>Patient Compliance</topic><topic>Patient Education as Topic</topic><topic>Postpartum period</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Self Care</topic><topic>self-management skills</topic><topic>Stress</topic><topic>Stress, Psychological</topic><topic>Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rand, Cynthia S., PhD</creatorcontrib><creatorcontrib>Wright, Rosalind J., MD, MPH</creatorcontrib><creatorcontrib>Cabana, Michael D., MD, MPH</creatorcontrib><creatorcontrib>Foggs, Michael B., MD</creatorcontrib><creatorcontrib>Halterman, Jill S., MD, MPH</creatorcontrib><creatorcontrib>Olson, Lynn, PhD</creatorcontrib><creatorcontrib>Vollmer, William M., PhD</creatorcontrib><creatorcontrib>Wilson, Sandra R., PhD</creatorcontrib><creatorcontrib>Taggart, Virginia, MPH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rand, Cynthia S., PhD</au><au>Wright, Rosalind J., MD, MPH</au><au>Cabana, Michael D., MD, MPH</au><au>Foggs, Michael B., MD</au><au>Halterman, Jill S., MD, MPH</au><au>Olson, Lynn, PhD</au><au>Vollmer, William M., PhD</au><au>Wilson, Sandra R., PhD</au><au>Taggart, Virginia, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediators of asthma outcomes</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>129</volume><issue>3</issue><spage>S136</spage><epage>S141</epage><pages>S136-S141</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Background Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. Objective National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. Methods We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. Results The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. Conclusions Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>22386506</pmid><doi>10.1016/j.jaci.2011.12.987</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adherence Allergy and Immunology Asthma - psychology Asthma - therapy asthma patient education Behavior Biomarkers Biomedical Research - standards Children & youth Clinical trials Depression Humans Managerial skills Mental depression Mortality Patient Compliance Patient Education as Topic Postpartum period Quality of life Questionnaires Self Care self-management skills Stress Stress, Psychological Studies Treatment Outcome |
| title | Mediators of asthma outcomes |
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