Skin-derived precursors generate enteric-type neurons in aganglionic jejunum

Abstract Purpose Skin-derived precursor cells (SKPs) may regenerate the enteric nervous system in Hirschsprung’s disease. SKPs migrate and differentiate into myenteric ganglia in aganglionic intestine. We sought to characterize the time-course of SKP gangliogenesis and enteric neurotransmitter synth...

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Veröffentlicht in:	Journal of pediatric surgery 2014-12, Vol.49 (12), p.1809-1814
Hauptverfasser:	Wagner, Justin P, Sullins, Veronica F, Dunn, James C.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aganglionosis Animals Animals, Newborn Cell Differentiation Cell-based therapy Cells, Cultured Disease Models, Animal Enteric Nervous System - cytology Female Ganglia, Parasympathetic - cytology Hirschsprung Disease - pathology Hirschsprung Disease - therapy Hirschsprung’s disease Jejunum - innervation Jejunum - pathology Neural Crest - cytology Pediatrics Rats Rats, Inbred Lew Regenerative medicine Skin - cytology Stem cell Stem Cell Transplantation - methods Surgery
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