PKCη promotes senescence induced by oxidative stress and chemotherapy

Senescence is characterized by permanent cell-cycle arrest despite continued viability and metabolic activity, in conjunction with the secretion of a complex mixture of extracellular proteins and soluble factors known as the senescence-associated secretory phenotype (SASP). Cellular senescence has b...

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Veröffentlicht in:	Cell death & disease 2014-11, Vol.5 (11), p.e1531-e1531
Hauptverfasser:	Zurgil, U, Ben-Ari, A, Atias, K, Isakov, N, Apte, R, Livneh, E
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14 14/34 38/109 38/89 631/67/1059/99 631/80/509 631/80/86/2366 82/1 82/29 82/80 96/106 96/109 Animals Antibiotics, Antineoplastic - pharmacology Antibodies beta-Galactosidase - genetics beta-Galactosidase - metabolism Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Cycle - drug effects Cell Cycle - genetics Cellular Senescence - drug effects Cellular Senescence - genetics Cercopithecus aethiops COS Cells Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism DNA Damage Doxorubicin - pharmacology Feedback, Physiological Gene Expression Regulation Genes, Reporter Humans Immunology Interleukin-6 - genetics Interleukin-6 - secretion Interleukin-8 - genetics Interleukin-8 - metabolism Life Sciences MCF-7 Cells Original original-article Oxidative Stress Plasmids Protein Kinase C - genetics Protein Kinase C - metabolism Receptors, Interleukin-6 - genetics Receptors, Interleukin-6 - metabolism Signal Transduction Transfection
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