IFN-γ induces aberrant CD49b+ NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-γ provokes pregnancy failure

Interferon- γ (IFN- γ ), a pleiotropic lymphokine, has important regulatory effects on many cell types. Although IFN- γ is essential for the initiation of uterine vascular modifications and maintenance of decidual integrity, IFN- γ administration can also cause pregnancy failure in many species. How...

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Veröffentlicht in:	Cell death & disease 2014-11, Vol.5 (11), p.e1512-e1512
Hauptverfasser:	Li, Z-Y, Chao, H-H, Liu, H-Y, Song, Z-H, Li, L-L, Zhang, Y-J, Yang, Y, Peng, J-P
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 14/19 38/77 631/250/1619/382 631/80/86 64/60 692/420/256 96/95 Abortion, Induced Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cells, Cultured Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Chemokine CX3CL1 - pharmacology Chemotaxis - drug effects CX3C Chemokine Receptor 1 Female Fetus Gene Expression Regulation Immunology Integrin alpha2 - genetics Integrin alpha2 - metabolism Interferon-gamma - genetics Interferon-gamma - metabolism Interferon-gamma - pharmacology Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Life Sciences Mice Mice, Inbred BALB C Original original-article Pregnancy Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, Mitogen - genetics Receptors, Mitogen - metabolism Signal Transduction STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Stromal Cells - cytology Stromal Cells - drug effects Stromal Cells - metabolism Uterus - cytology Uterus - drug effects Uterus - metabolism
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