Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

Multiple subsets of FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent dendritic cells (DCs) control T-cell tolerance and immunity. In mice, Batf3-dependent CD103+ DCs efficiently enter lymph nodes and cross-present antigens, rendering this conserved DC subset a promising target for tolerance induc...

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Veröffentlicht in:	Blood 2014-11, Vol.124 (20), p.3081-3091
Hauptverfasser:	Mayer, Christian Thomas, Ghorbani, Peyman, Nandan, Amrita, Dudek, Markus, Arnold-Schrauf, Catharina, Hesse, Christina, Berod, Luciana, Stüve, Philipp, Puttur, Franz, Merad, Miriam, Sparwasser, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - analysis Antigens, CD - immunology Basic-Leucine Zipper Transcription Factors - analysis Basic-Leucine Zipper Transcription Factors - immunology Bone Marrow Cells - cytology Cell Culture Techniques - methods Cell Differentiation Cells, Cultured Dendritic Cells - cytology Dendritic Cells - immunology Granulocyte-Macrophage Colony-Stimulating Factor - immunology Immunity, Cellular Immunobiology Integrin alpha Chains - analysis Integrin alpha Chains - immunology Membrane Proteins - immunology Mice Repressor Proteins - analysis Repressor Proteins - immunology T-Lymphocytes - immunology Toll-Like Receptor 3 - immunology
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