BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

Genome maintenance by homologous recombination depends on coordinating many proteins in time and space to assemble at DNA break sites. To understand this process, we followed the mobility of BRCA2, a critical recombination mediator, in live cells at the single-molecule level using both single-partic...

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Veröffentlicht in:	The Journal of cell biology 2014-12, Vol.207 (5), p.599-613
Hauptverfasser:	Reuter, Marcel, Zelensky, Alex, Smal, Ihor, Meijering, Erik, van Cappellen, Wiggert A, de Gruiter, H Martijn, van Belle, Gijsbert J, van Royen, Martin E, Houtsmuller, Adriaan B, Essers, Jeroen, Kanaar, Roland, Wyman, Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites BRCA2 Protein - metabolism Comparative analysis DNA Damage Embryonic Stem Cells - metabolism Genomics Green Fluorescent Proteins - metabolism HeLa Cells Humans Mice Mice, 129 Strain Microscopy, Fluorescence Microscopy, Video Motility Protein Aggregates Protein Binding Protein expression Protein Transport Rad51 Recombinase - metabolism Recombinant Fusion Proteins - metabolism Single-Cell Analysis Spectrum analysis
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