Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis
The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility. A systematic search of electronic databases (PubMed, EMBASE, Wanfa...
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| Veröffentlicht in: | Medical science monitor 2014-11, Vol.20, p.2461-2465 |
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| creator | Zhao, Junfei Wang, Hongyuan Hu, Weizhen Jin, Yuanhong |
| description | The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility.
A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P |
| doi_str_mv | 10.12659/MSM.891141 |
| format | Article |
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A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P<0.01).
This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.891141</identifier><identifier>PMID: 25430685</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Genetic Predisposition to Disease ; Humans ; Lung Neoplasms - genetics ; Meta-Analysis ; Molecular Chaperones - genetics ; Polymorphism, Single Nucleotide - genetics ; Risk Factors</subject><ispartof>Medical science monitor, 2014-11, Vol.20, p.2461-2465</ispartof><rights>Med Sci Monit, 2014 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-1fe8b8ac71fab20c5426583b2bad05c8b481710ebe992a65f1782ae3f47e1be53</citedby><cites>FETCH-LOGICAL-c381t-1fe8b8ac71fab20c5426583b2bad05c8b481710ebe992a65f1782ae3f47e1be53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259522/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259522/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25430685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Junfei</creatorcontrib><creatorcontrib>Wang, Hongyuan</creatorcontrib><creatorcontrib>Hu, Weizhen</creatorcontrib><creatorcontrib>Jin, Yuanhong</creatorcontrib><title>Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility.
A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P<0.01).
This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.</description><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Meta-Analysis</subject><subject>Molecular Chaperones - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctLxDAQxoMovk_eJUdBqnk0bepBWMUXrHhQL17CNDvRaNvUpCvsf29xVfQ0A_Pjm2_mI2SPsyMuClUd397fHumK85yvkE1e5DKTpWKrf_oNspXSK2NCF0ytkw2hcskKrTbJ04VzaAcaHL2eTrKzDFIK1sOAMzpE6JKNvh-opH1oFm2I_YtPbaKho828e6YWOouRRp_eTijQFgfIoINmkXzaIWsOmoS733WbPF5ePJxfZ9O7q5vzyTSzUvMh4w51rcGW3EEtmFX5eJSWtahhxpTVda55yRnWWFUCCuV4qQWgdHmJvEYlt8npUref1y3OLHaj8cb00bcQFyaAN_8nnX8xz-HD5EJVSohR4OBbIIb3OabBtD5ZbBroMMyT4YXQWgtWlCN6uERtDClFdL9rODNfaZgxDbNMY6T3_zr7ZX_eLz8BD3-GLw</recordid><startdate>20141128</startdate><enddate>20141128</enddate><creator>Zhao, Junfei</creator><creator>Wang, Hongyuan</creator><creator>Hu, Weizhen</creator><creator>Jin, Yuanhong</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141128</creationdate><title>Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis</title><author>Zhao, Junfei ; Wang, Hongyuan ; Hu, Weizhen ; Jin, Yuanhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-1fe8b8ac71fab20c5426583b2bad05c8b481710ebe992a65f1782ae3f47e1be53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Meta-Analysis</topic><topic>Molecular Chaperones - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Junfei</creatorcontrib><creatorcontrib>Wang, Hongyuan</creatorcontrib><creatorcontrib>Hu, Weizhen</creatorcontrib><creatorcontrib>Jin, Yuanhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Junfei</au><au>Wang, Hongyuan</au><au>Hu, Weizhen</au><au>Jin, Yuanhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2014-11-28</date><risdate>2014</risdate><volume>20</volume><spage>2461</spage><epage>2465</epage><pages>2461-2465</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate. We conducted a meta-analysis to evaluate the association between these polymorphisms and lung cancer susceptibility.
A systematic search of electronic databases (PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure) was performed. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
Ten case-control studies with 37 945 and 56 807 controls were included in this meta-analysis. Overall, a significant association between rs1052486 polymorphism and lung cancer susceptibility was observed (OR=1.07, 95% CI 1.01-1.12, P=0.01). In addition, a significant association was found for rs3117582 polymorphism (OR=1.29, 95% CI 1.22-1.37, P<0.01).
This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>25430685</pmid><doi>10.12659/MSM.891141</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medical science monitor, 2014-11, Vol.20, p.2461-2465 |
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| language | eng |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Genetic Predisposition to Disease Humans Lung Neoplasms - genetics Meta-Analysis Molecular Chaperones - genetics Polymorphism, Single Nucleotide - genetics Risk Factors |
| title | Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis |
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