SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma

SapC-DOPS is a novel nanotherapeutic that has been shown to target and induce cell death in a variety of cancers, including glioblastoma (GBM). GBM is a primary brain tumor known to frequently demonstrate resistance to apoptosis-inducing therapeutics. Here we explore the mode of action for SapC-DOPS...

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Veröffentlicht in:	Oncotarget 2014-10, Vol.5 (20), p.9703-9709
Hauptverfasser:	Wojton, Jeffrey, Meisen, Walter Hans, Jacob, Naduparambil K, Thorne, Amy Haseley, Hardcastle, Jayson, Denton, Nicholas, Chu, Zhengtao, Dmitrieva, Nina, Marsh, Rachel, Van Meir, Erwin G, Kwon, Chang-Hyuk, Chakravarti, Arnab, Qi, Xiaoyang, Kaur, Balveen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Death - drug effects Cell Line, Tumor Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Drug Synergism Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Humans Lysosomes - drug effects Mice Mice, Nude Nanostructures - administration & dosage Phosphatidylserines - pharmacology Random Allocation Research Paper Saposins - administration & dosage Saposins - pharmacology Xenograft Model Antitumor Assays
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