The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units
Daily rhythms in behavior emerge from networks of neurons that express molecular clocks. Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two hierarchically organized groups, one of which serves as a master pacemaker. Here, we establish that the fly...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2014-03, Vol.343 (6178), p.1516-1520 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1520 |
|---|---|
| container_issue | 6178 |
| container_start_page | 1516 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 343 |
| creator | Yao, Z. Shafer, O. T. |
| description | Daily rhythms in behavior emerge from networks of neurons that express molecular clocks. Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two hierarchically organized groups, one of which serves as a master pacemaker. Here, we establish that the fly's clock neuron network consists of multiple units of independent neuronal oscillators, each unified by its neuropeptide transmitter and mode of coupling to other units. Our work reveals that the circadian clock neuron network is not orchestrated by a small group of master pacemakers but rather consists of multiple independent oscillators, each of which drives rhythms in activity. |
| doi_str_mv | 10.1126/science.1251285 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4259399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>24743538</jstor_id><sourcerecordid>24743538</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-26fb03cfa4544de23260a376873f640ccbb56801eea2b6daf6dc944f7cb91a803</originalsourceid><addsrcrecordid>eNpdkc1P3DAQxS1EVZZtzz21stQLl4C_HV-QqhRaJPpxgB64WI7jsF68cWonIP77Gu0W0Z5Gmvebp5l5ALzD6BhjIk6y9W6w7hgTjknN98ACI8UrRRDdBwuEqKhqJPkBOMx5jVDRFH0NDggTkiuBF-DmauXg5xRzHFc-GNj4ZE3nzQCbEO0dvMjQwF8medOGR9jEeQyug9_d9BDTHYw9_DaHyZcm_OnGyXcu3XoLrwc_5TfgVW9Cdm93dQmuz8-umq_V5Y8vF82ny8oyRqeKiL5F1PaGccY6RygRyFApakl7wZC1bctFjbBzhrSiM73orGKsl7ZV2NSILsHp1nec243rrBumZIIek9-Y9Kij8fpfZfArfRvvNSPlG0oVg6OdQYq_Z5cnvfHZuhDM4OKcNeYYU8VIWXcJPv6HruOchnLeE4UkY1jKQp1sKVsem5Prn5fBSD_lpne56V1uZeLDyxue-b9BFeD9FljnKaYXumSU05r-AXlHn0o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1510744177</pqid></control><display><type>article</type><title>The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Yao, Z. ; Shafer, O. T.</creator><creatorcontrib>Yao, Z. ; Shafer, O. T.</creatorcontrib><description>Daily rhythms in behavior emerge from networks of neurons that express molecular clocks. Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two hierarchically organized groups, one of which serves as a master pacemaker. Here, we establish that the fly's clock neuron network consists of multiple units of independent neuronal oscillators, each unified by its neuropeptide transmitter and mode of coupling to other units. Our work reveals that the circadian clock neuron network is not orchestrated by a small group of master pacemakers but rather consists of multiple independent oscillators, each of which drives rhythms in activity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1251285</identifier><identifier>PMID: 24675961</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Brain ; Circadian Clocks ; Circadian Rhythm ; Clocks ; Comparison tests ; Drosophila ; Drosophila melanogaster - cytology ; Drosophila melanogaster - physiology ; Genotypes ; Insects ; Molecular biology ; Nerve Net ; Networks ; Neurons ; Neurons - physiology ; Neuropeptides ; Neuropeptides - physiology ; Oscillators ; Periodicity ; Scatter plots ; Synaptic Transmission</subject><ispartof>Science (American Association for the Advancement of Science), 2014-03, Vol.343 (6178), p.1516-1520</ispartof><rights>Copyright © 2014 American Association for the Advancement of Science</rights><rights>Copyright © 2014, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-26fb03cfa4544de23260a376873f640ccbb56801eea2b6daf6dc944f7cb91a803</citedby><cites>FETCH-LOGICAL-c443t-26fb03cfa4544de23260a376873f640ccbb56801eea2b6daf6dc944f7cb91a803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24743538$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24743538$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24675961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Z.</creatorcontrib><creatorcontrib>Shafer, O. T.</creatorcontrib><title>The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Daily rhythms in behavior emerge from networks of neurons that express molecular clocks. Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two hierarchically organized groups, one of which serves as a master pacemaker. Here, we establish that the fly's clock neuron network consists of multiple units of independent neuronal oscillators, each unified by its neuropeptide transmitter and mode of coupling to other units. Our work reveals that the circadian clock neuron network is not orchestrated by a small group of master pacemakers but rather consists of multiple independent oscillators, each of which drives rhythms in activity.</description><subject>Animals</subject><subject>Brain</subject><subject>Circadian Clocks</subject><subject>Circadian Rhythm</subject><subject>Clocks</subject><subject>Comparison tests</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - physiology</subject><subject>Genotypes</subject><subject>Insects</subject><subject>Molecular biology</subject><subject>Nerve Net</subject><subject>Networks</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neuropeptides</subject><subject>Neuropeptides - physiology</subject><subject>Oscillators</subject><subject>Periodicity</subject><subject>Scatter plots</subject><subject>Synaptic Transmission</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1P3DAQxS1EVZZtzz21stQLl4C_HV-QqhRaJPpxgB64WI7jsF68cWonIP77Gu0W0Z5Gmvebp5l5ALzD6BhjIk6y9W6w7hgTjknN98ACI8UrRRDdBwuEqKhqJPkBOMx5jVDRFH0NDggTkiuBF-DmauXg5xRzHFc-GNj4ZE3nzQCbEO0dvMjQwF8medOGR9jEeQyug9_d9BDTHYw9_DaHyZcm_OnGyXcu3XoLrwc_5TfgVW9Cdm93dQmuz8-umq_V5Y8vF82ny8oyRqeKiL5F1PaGccY6RygRyFApakl7wZC1bctFjbBzhrSiM73orGKsl7ZV2NSILsHp1nec243rrBumZIIek9-Y9Kij8fpfZfArfRvvNSPlG0oVg6OdQYq_Z5cnvfHZuhDM4OKcNeYYU8VIWXcJPv6HruOchnLeE4UkY1jKQp1sKVsem5Prn5fBSD_lpne56V1uZeLDyxue-b9BFeD9FljnKaYXumSU05r-AXlHn0o</recordid><startdate>20140328</startdate><enddate>20140328</enddate><creator>Yao, Z.</creator><creator>Shafer, O. T.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140328</creationdate><title>The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units</title><author>Yao, Z. ; Shafer, O. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-26fb03cfa4544de23260a376873f640ccbb56801eea2b6daf6dc944f7cb91a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Brain</topic><topic>Circadian Clocks</topic><topic>Circadian Rhythm</topic><topic>Clocks</topic><topic>Comparison tests</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - physiology</topic><topic>Genotypes</topic><topic>Insects</topic><topic>Molecular biology</topic><topic>Nerve Net</topic><topic>Networks</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neuropeptides</topic><topic>Neuropeptides - physiology</topic><topic>Oscillators</topic><topic>Periodicity</topic><topic>Scatter plots</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Z.</creatorcontrib><creatorcontrib>Shafer, O. T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Z.</au><au>Shafer, O. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2014-03-28</date><risdate>2014</risdate><volume>343</volume><issue>6178</issue><spage>1516</spage><epage>1520</epage><pages>1516-1520</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Daily rhythms in behavior emerge from networks of neurons that express molecular clocks. Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two hierarchically organized groups, one of which serves as a master pacemaker. Here, we establish that the fly's clock neuron network consists of multiple units of independent neuronal oscillators, each unified by its neuropeptide transmitter and mode of coupling to other units. Our work reveals that the circadian clock neuron network is not orchestrated by a small group of master pacemakers but rather consists of multiple independent oscillators, each of which drives rhythms in activity.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>24675961</pmid><doi>10.1126/science.1251285</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2014-03, Vol.343 (6178), p.1516-1520 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4259399 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Brain Circadian Clocks Circadian Rhythm Clocks Comparison tests Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - physiology Genotypes Insects Molecular biology Nerve Net Networks Neurons Neurons - physiology Neuropeptides Neuropeptides - physiology Oscillators Periodicity Scatter plots Synaptic Transmission |
| title | The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T11%3A07%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Drosophila%20Circadian%20Clock%20Is%20a%20Variably%20Coupled%20Network%20of%20Multiple%20Peptidergic%20Units&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Yao,%20Z.&rft.date=2014-03-28&rft.volume=343&rft.issue=6178&rft.spage=1516&rft.epage=1520&rft.pages=1516-1520&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1251285&rft_dat=%3Cjstor_pubme%3E24743538%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1510744177&rft_id=info:pmid/24675961&rft_jstor_id=24743538&rfr_iscdi=true |