Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma
AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-12, Vol.20 (45), p.17132-17140 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Han, Jae Hyun Kim, Dong Goo Na, Gun Hyung Kim, Eun Young Lee, Soo Ho Hong, Tae Ho You, Young Kyoung |
| description | AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative intent at our hospital.We evaluated preoperative prognostic factors associated with histologic grade of tumor,recurrence and survival,especially the findings of pre-operative imaging studies such as positron emission tomography-computed tomography(PETCT)and magnetic resonance imaging(MRI).And then,we established a scoring system to predict recurrence and survival after surgery dividing the patients into two groups based on a tumor size of 5 cm.RESULTS:Of the 298 patients,129(43.3%)developed recurrence during the follow-up period.The 5 year disease free survival and overall survival were 47.0%and58.7%respectively.In multivariate analysis,a serum alpha-fetoprotein(AFP)level of>100 ng/m L and a standardized uptake value(SUV)of PET-CT of>3.5 were predictive factors for histologic grade of tumor,recurrence,and survival.Tumor size of>5 cm and a relative enhancement ratio(RER)calculated from preoperative MRI were also significantly associated with prognosis in univariate analysis.We established a scoring system to predict prognosis using AFP,SUV,and RER.In those with tumors of>5 cm,it showed predicted both recurrence(P=0.005)and survival(P=0.001).CONCLUSION:The AFP,tumor size,SUV and RER are useful for prognosis preoperatively.An accurate prediction of prognosis is possible using our scoring system in large size tumors. |
| doi_str_mv | 10.3748/wjg.v20.i45.17132 |
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All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-46499ea005e73dc07f3e9724aa4dd8c69c4cf4eeec71b28e6b61e9796f03a0243</citedby><cites>FETCH-LOGICAL-c509t-46499ea005e73dc07f3e9724aa4dd8c69c4cf4eeec71b28e6b61e9796f03a0243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258583/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258583/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25493027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Jae Hyun</creatorcontrib><creatorcontrib>Kim, Dong Goo</creatorcontrib><creatorcontrib>Na, Gun Hyung</creatorcontrib><creatorcontrib>Kim, Eun Young</creatorcontrib><creatorcontrib>Lee, Soo Ho</creatorcontrib><creatorcontrib>Hong, Tae Ho</creatorcontrib><creatorcontrib>You, Young Kyoung</creatorcontrib><title>Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative intent at our hospital.We evaluated preoperative prognostic factors associated with histologic grade of tumor,recurrence and survival,especially the findings of pre-operative imaging studies such as positron emission tomography-computed tomography(PETCT)and magnetic resonance imaging(MRI).And then,we established a scoring system to predict recurrence and survival after surgery dividing the patients into two groups based on a tumor size of 5 cm.RESULTS:Of the 298 patients,129(43.3%)developed recurrence during the follow-up period.The 5 year disease free survival and overall survival were 47.0%and58.7%respectively.In multivariate analysis,a serum alpha-fetoprotein(AFP)level of&gt;100 ng/m L and a standardized uptake value(SUV)of PET-CT of&gt;3.5 were predictive factors for histologic grade of tumor,recurrence,and survival.Tumor size of&gt;5 cm and a relative enhancement ratio(RER)calculated from preoperative MRI were also significantly associated with prognosis in univariate analysis.We established a scoring system to predict prognosis using AFP,SUV,and RER.In those with tumors of&gt;5 cm,it showed predicted both recurrence(P=0.005)and survival(P=0.001).CONCLUSION:The AFP,tumor size,SUV and RER are useful for prognosis preoperatively.An accurate prediction of prognosis is possible using our scoring system in large size tumors.</description><subject>Aged</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Carcinoma</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Chi-Square Distribution</subject><subject>Decision Support Techniques</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - mortality</subject><subject>Hepatocellular</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local</subject><subject>Patient Selection</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Prognostic</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Retrospective Study</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU2PEyEYx4nRuHX1A3gxc_Qy9eFtgIuJ2awvySZe9EwofZiymUIXZmr89kvd2igcCPm_PJAfIW8prLkS-sOv-3F9ZLCOQq6popw9IyvGqOmZFvCcrCiA6g1n6oq8qvUegHEu2UtyxaQwHJhaEbw9umlxc8ypy6E7lDymXOfou-D8nEvtmlDQL6Vg8ti5MGPp2rVFjtiUiv4Url3Ipdvhwc3Z4zQtk2s2V3xMee9ekxfBTRXfnM9r8vPz7Y-br_3d9y_fbj7d9V6CmXsxCGPQAUhUfOtBBY5GMeGc2G61H4wXPghE9IpumMZhM9BmMEMA7oAJfk0-PvUels0etx7TXNxkDyXuXflts4v2fyXFnR3z0QomtdS8Fbw_F5T8sGCd7T7W039cwrxUSwcugVImh2alT1Zfcq0Fw2UMBXvCYxse2_DYhsf-wdMy7_593yXxl0cz8HPpLqfxIabx4jGgT8tIEFoYydrmQksqOX8EE8Gfqg</recordid><startdate>20141207</startdate><enddate>20141207</enddate><creator>Han, Jae Hyun</creator><creator>Kim, Dong Goo</creator><creator>Na, Gun Hyung</creator><creator>Kim, Eun Young</creator><creator>Lee, Soo Ho</creator><creator>Hong, Tae Ho</creator><creator>You, Young Kyoung</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141207</creationdate><title>Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma</title><author>Han, Jae Hyun ; Kim, Dong Goo ; Na, Gun Hyung ; Kim, Eun Young ; Lee, Soo Ho ; Hong, Tae Ho ; You, Young Kyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-46499ea005e73dc07f3e9724aa4dd8c69c4cf4eeec71b28e6b61e9796f03a0243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Carcinoma</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Chi-Square Distribution</topic><topic>Decision Support Techniques</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - mortality</topic><topic>Hepatocellular</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local</topic><topic>Patient Selection</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prognostic</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Retrospective Study</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><toplevel>online_resources</toplevel><creatorcontrib>Han, Jae Hyun</creatorcontrib><creatorcontrib>Kim, Dong Goo</creatorcontrib><creatorcontrib>Na, Gun Hyung</creatorcontrib><creatorcontrib>Kim, Eun Young</creatorcontrib><creatorcontrib>Lee, Soo Ho</creatorcontrib><creatorcontrib>Hong, Tae Ho</creatorcontrib><creatorcontrib>You, Young Kyoung</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jae Hyun</au><au>Kim, Dong Goo</au><au>Na, Gun Hyung</au><au>Kim, Eun Young</au><au>Lee, Soo Ho</au><au>Hong, Tae Ho</au><au>You, Young Kyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-12-07</date><risdate>2014</risdate><volume>20</volume><issue>45</issue><spage>17132</spage><epage>17140</epage><pages>17132-17140</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To select appropriate patients before surgical resection for hepatocellular carcinoma(HCC),especially those with advanced tumors.METHODS:From January 2000 to December 2012,we retrospectively analyzed the medical records of 298 patients who had undergone surgical resections for HCC with curative intent at our hospital.We evaluated preoperative prognostic factors associated with histologic grade of tumor,recurrence and survival,especially the findings of pre-operative imaging studies such as positron emission tomography-computed tomography(PETCT)and magnetic resonance imaging(MRI).And then,we established a scoring system to predict recurrence and survival after surgery dividing the patients into two groups based on a tumor size of 5 cm.RESULTS:Of the 298 patients,129(43.3%)developed recurrence during the follow-up period.The 5 year disease free survival and overall survival were 47.0%and58.7%respectively.In multivariate analysis,a serum alpha-fetoprotein(AFP)level of&gt;100 ng/m L and a standardized uptake value(SUV)of PET-CT of&gt;3.5 were predictive factors for histologic grade of tumor,recurrence,and survival.Tumor size of&gt;5 cm and a relative enhancement ratio(RER)calculated from preoperative MRI were also significantly associated with prognosis in univariate analysis.We established a scoring system to predict prognosis using AFP,SUV,and RER.In those with tumors of&gt;5 cm,it showed predicted both recurrence(P=0.005)and survival(P=0.001).CONCLUSION:The AFP,tumor size,SUV and RER are useful for prognosis preoperatively.An accurate prediction of prognosis is possible using our scoring system in large size tumors.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25493027</pmid><doi>10.3748/wjg.v20.i45.17132</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged alpha-Fetoproteins - analysis Carcinoma Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Chi-Square Distribution Decision Support Techniques Disease-Free Survival Female Hepatectomy Hepatectomy - adverse effects Hepatectomy - mortality Hepatocellular Humans Kaplan-Meier Estimate Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Logistic Models Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Neoplasm Grading Neoplasm Recurrence, Local Patient Selection Positron-Emission Tomography Predictive Value of Tests Prognostic Proportional Hazards Models Retrospective Studies Retrospective Study Risk Assessment Risk Factors Time Factors Tomography, X-Ray Computed Treatment Outcome Tumor Burden |
| title | Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma |
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