Applying horizontal gene transfer phenomena to enhance non-viral gene therapy

Horizontal gene transfer (HGT) is widespread amongst prokaryotes, but eukaryotes tend to be far less promiscuous with their genetic information. However, several examples of HGT from pathogens into eukaryotic cells have been discovered and mimicked to improve non-viral gene delivery techniques. For...

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Veröffentlicht in:	Journal of controlled release 2013-11, Vol.172 (1), p.246-257
Hauptverfasser:	Elmer, Jacob J., Christensen, Matthew D., Rege, Kaushal
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrobacterium radiobacter Agrobacterium tumefaciens Agrobacterium tumefaciens - genetics Agrobacterium tumefaciens - physiology Animals bacteria Bartonella henselae Bartonella henselae - genetics Bartonella henselae - physiology DNA eukaryotic cells gene therapy Gene Transfer, Horizontal genes genetic disorders genetic engineering Genetic Therapy - methods Horizontal gene transfer Host-Pathogen Interactions Humans Mimicry Non-viral gene delivery nucleotide sequences parasites pathogens Plants - microbiology prokaryotic cells Transgenes Trypanosoma cruzi Trypanosoma cruzi - genetics Trypanosoma cruzi - physiology viral proteins Virus Physiological Phenomena viruses Viruses - genetics
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