Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C...

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Veröffentlicht in:	Cell 2014-01, Vol.156 (3), p.456-468
Hauptverfasser:	Schiwon, Marzena, Weisheit, Christina, Franken, Lars, Gutweiler, Sebastian, Dixit, Akanksha, Meyer-Schwesinger, Catherine, Pohl, Judith-Mira, Maurice, Nicholas J., Thiebes, Stephanie, Lorenz, Kristina, Quast, Thomas, Fuhrmann, Martin, Baumgarten, Georg, Lohse, Martin J., Opdenakker, Ghislain, Bernhagen, Jürgen, Bucala, Rick, Panzer, Ulf, Kolanus, Waldemar, Gröne, Hermann-Josef, Garbi, Natalio, Kastenmüller, Wolfgang, Knolle, Percy A., Kurts, Christian, Engel, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Animals Antigens, Ly - metabolism bacteria bacterial infections Bacterial Infections - immunology CD4-positive T-lymphocytes chemokine CXCL2 Chemokine CXCL2 - immunology epithelium Female gelatinase B Immune System Diseases innate immunity Kinetics Leukocyte Disorders macrophages Macrophages - cytology Macrophages - immunology Matrix Metalloproteinase 9 - metabolism Mice neutrophils Neutrophils - cytology Neutrophils - immunology Specific Pathogen-Free Organisms Tumor Necrosis Factor-alpha - immunology tumor necrosis factors urinary tract diseases Urinary Tract Infections - immunology
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