Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double‐blind, placebo‐controlled trial
Lipopolysaccharide from Pantoea agglomerans (LPSp) facilitates Ca and P turnover in chicken calvaria and femurs. This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Using ovariectomized (OVX) osteoporosis mice model, we inves...
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| Veröffentlicht in: | Food Science & Nutrition 2014-11, Vol.2 (6), p.638-646 |
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| creator | Nakata, Kazue Nakata, Yoko Inagawa, Hiroyuki Nakamoto, Takeru Yoshimura, Hiroshi Soma, Gen‐Ichiro |
| description | Lipopolysaccharide from Pantoea agglomerans (LPSp) facilitates Ca and P turnover in chicken calvaria and femurs. This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp‐containing water for 4 weeks. Oral administration of LPSp tended to suppress the decline in the bone density and the cortical bone thickness in the OVX mice. Moreover, the Ca concentrations were maintained in the OVX‐LPSp mice. The effects of LPSp on bone turnover were tested in randomized and double‐blind clinical test subjects, who were healthy women aged 40–79 years. The subjects ingested either soy milk without LPSp (control group) or with LPSp (LPSp group) for 3 months. The results showed that the LPSp group on premenopause maintained their bone density compared with the control group pre‐ and postmenopause. Moreover, these effects were maintained for 2 months postobservation. LPSp maintains bone volume and density in vivo. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.
This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention. |
| doi_str_mv | 10.1002/fsn3.145 |
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This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.145</identifier><identifier>PMID: 25493180</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Analysis ; Apoptosis ; Biomedical materials ; Blindness ; Bone density ; Bone turnover ; Bones ; Calvaria ; Cancer ; Cortical bone ; Density ; Double-blind studies ; Flour ; Food ; Fractures ; Health aspects ; Homeostasis ; In vivo methods and tests ; Lipopolysaccharides ; LPS ; Menopause ; Metabolism ; Mice ; Oncology, Experimental ; Oral administration ; Original Research ; Osteoporosis ; Ovariectomy ; Pantoea agglomerans ; Plant-based beverages ; Post-menopause ; Poultry ; Premenopause ; Prevention ; Randomization ; soy milk ; Soy products ; Soya bean milk ; Studies ; Women</subject><ispartof>Food Science & Nutrition, 2014-11, Vol.2 (6), p.638-646</ispartof><rights>2014 The Authors. published by Wiley Periodicals, Inc.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>2014. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 The Authors. published by Wiley Periodicals, Inc. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5055-7c45fc04c7f854715274ab268596908df8f3a50a61b9e68d71c89386205f79bf3</citedby><cites>FETCH-LOGICAL-c5055-7c45fc04c7f854715274ab268596908df8f3a50a61b9e68d71c89386205f79bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256567/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256567/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25493180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakata, Kazue</creatorcontrib><creatorcontrib>Nakata, Yoko</creatorcontrib><creatorcontrib>Inagawa, Hiroyuki</creatorcontrib><creatorcontrib>Nakamoto, Takeru</creatorcontrib><creatorcontrib>Yoshimura, Hiroshi</creatorcontrib><creatorcontrib>Soma, Gen‐Ichiro</creatorcontrib><title>Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double‐blind, placebo‐controlled trial</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Lipopolysaccharide from Pantoea agglomerans (LPSp) facilitates Ca and P turnover in chicken calvaria and femurs. This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp‐containing water for 4 weeks. Oral administration of LPSp tended to suppress the decline in the bone density and the cortical bone thickness in the OVX mice. Moreover, the Ca concentrations were maintained in the OVX‐LPSp mice. The effects of LPSp on bone turnover were tested in randomized and double‐blind clinical test subjects, who were healthy women aged 40–79 years. The subjects ingested either soy milk without LPSp (control group) or with LPSp (LPSp group) for 3 months. The results showed that the LPSp group on premenopause maintained their bone density compared with the control group pre‐ and postmenopause. Moreover, these effects were maintained for 2 months postobservation. LPSp maintains bone volume and density in vivo. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.
This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.</description><subject>Analysis</subject><subject>Apoptosis</subject><subject>Biomedical materials</subject><subject>Blindness</subject><subject>Bone density</subject><subject>Bone turnover</subject><subject>Bones</subject><subject>Calvaria</subject><subject>Cancer</subject><subject>Cortical bone</subject><subject>Density</subject><subject>Double-blind studies</subject><subject>Flour</subject><subject>Food</subject><subject>Fractures</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>In vivo methods and tests</subject><subject>Lipopolysaccharides</subject><subject>LPS</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Oncology, Experimental</subject><subject>Oral administration</subject><subject>Original Research</subject><subject>Osteoporosis</subject><subject>Ovariectomy</subject><subject>Pantoea agglomerans</subject><subject>Plant-based beverages</subject><subject>Post-menopause</subject><subject>Poultry</subject><subject>Premenopause</subject><subject>Prevention</subject><subject>Randomization</subject><subject>soy milk</subject><subject>Soy products</subject><subject>Soya bean 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Kazue</creator><creator>Nakata, Yoko</creator><creator>Inagawa, Hiroyuki</creator><creator>Nakamoto, Takeru</creator><creator>Yoshimura, Hiroshi</creator><creator>Soma, Gen‐Ichiro</creator><general>John Wiley & Sons, Inc</general><general>BlackWell Publishing 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density in premenopausal women: a randomized, double‐blind, placebo‐controlled trial</title><author>Nakata, Kazue ; Nakata, Yoko ; Inagawa, Hiroyuki ; Nakamoto, Takeru ; Yoshimura, Hiroshi ; Soma, Gen‐Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5055-7c45fc04c7f854715274ab268596908df8f3a50a61b9e68d71c89386205f79bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Apoptosis</topic><topic>Biomedical materials</topic><topic>Blindness</topic><topic>Bone density</topic><topic>Bone turnover</topic><topic>Bones</topic><topic>Calvaria</topic><topic>Cancer</topic><topic>Cortical bone</topic><topic>Density</topic><topic>Double-blind studies</topic><topic>Flour</topic><topic>Food</topic><topic>Fractures</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>In vivo methods and tests</topic><topic>Lipopolysaccharides</topic><topic>LPS</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Oncology, Experimental</topic><topic>Oral administration</topic><topic>Original Research</topic><topic>Osteoporosis</topic><topic>Ovariectomy</topic><topic>Pantoea agglomerans</topic><topic>Plant-based beverages</topic><topic>Post-menopause</topic><topic>Poultry</topic><topic>Premenopause</topic><topic>Prevention</topic><topic>Randomization</topic><topic>soy milk</topic><topic>Soy products</topic><topic>Soya bean milk</topic><topic>Studies</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakata, Kazue</creatorcontrib><creatorcontrib>Nakata, Yoko</creatorcontrib><creatorcontrib>Inagawa, Hiroyuki</creatorcontrib><creatorcontrib>Nakamoto, Takeru</creatorcontrib><creatorcontrib>Yoshimura, Hiroshi</creatorcontrib><creatorcontrib>Soma, Gen‐Ichiro</creatorcontrib><collection>Wiley Online 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trial</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2014-11</date><risdate>2014</risdate><volume>2</volume><issue>6</issue><spage>638</spage><epage>646</epage><pages>638-646</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Lipopolysaccharide from Pantoea agglomerans (LPSp) facilitates Ca and P turnover in chicken calvaria and femurs. This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp‐containing water for 4 weeks. Oral administration of LPSp tended to suppress the decline in the bone density and the cortical bone thickness in the OVX mice. Moreover, the Ca concentrations were maintained in the OVX‐LPSp mice. The effects of LPSp on bone turnover were tested in randomized and double‐blind clinical test subjects, who were healthy women aged 40–79 years. The subjects ingested either soy milk without LPSp (control group) or with LPSp (LPSp group) for 3 months. The results showed that the LPSp group on premenopause maintained their bone density compared with the control group pre‐ and postmenopause. Moreover, these effects were maintained for 2 months postobservation. LPSp maintains bone volume and density in vivo. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.
This study investigated osteoporosis prevention by the oral administration of LPSp in mice and in double‐blind clinical tests. Thus, a combination of soy milk and LPSp may be useful for osteoporosis prevention.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>25493180</pmid><doi>10.1002/fsn3.145</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Apoptosis Biomedical materials Blindness Bone density Bone turnover Bones Calvaria Cancer Cortical bone Density Double-blind studies Flour Food Fractures Health aspects Homeostasis In vivo methods and tests Lipopolysaccharides LPS Menopause Metabolism Mice Oncology, Experimental Oral administration Original Research Osteoporosis Ovariectomy Pantoea agglomerans Plant-based beverages Post-menopause Poultry Premenopause Prevention Randomization soy milk Soy products Soya bean milk Studies Women |
| title | Pantoea agglomerans lipopolysaccharide maintains bone density in premenopausal women: a randomized, double‐blind, placebo‐controlled trial |
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