Class IIa Histone Deacetylases Are Conserved Regulators of Circadian Function

Class IIa histone deacetylases (HDACs) regulate the activity of many transcription factors to influence liver gluconeogenesis and the development of specialized cells, including muscle, neurons, and lymphocytes. Here, we describe a conserved role for class IIa HDACs in sustaining robust circadian be...

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Veröffentlicht in:	The Journal of biological chemistry 2014-12, Vol.289 (49), p.34341-34348
Hauptverfasser:	Fogg, Paul C.M., O'Neill, John S., Dobrzycki, Tomasz, Calvert, Shaun, Lord, Emma C., McIntosh, Rebecca L.L., Elliott, Christopher J.H., Sweeney, Sean T., Hastings, Michael H., Chawla, Sangeeta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Calcium - metabolism Cell Biology Circadian Clocks - genetics Circadian Rhythm Clock Gene CLOCK Proteins - genetics CLOCK Proteins - metabolism Conserved Sequence Cyclic AMP Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation Genes, Reporter Histone Deacetylase (HDAC) Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Luciferases - genetics Luciferases - metabolism Mice NIH 3T3 Cells Nuclear Translocation Period Circadian Proteins - genetics Period Circadian Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction
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