Protein-protein interfaces from cytochrome c oxidase I evolve faster than nonbinding surfaces, yet negative selection is the driving force

Respiratory complexes are encoded by two genomes (mitochondrial DNA [mtDNA] and nuclear DNA [nDNA]). Although the importance of intergenomic coadaptation is acknowledged, the forces and constraints shaping such coevolution are largely unknown. Previous works using cytochrome c oxidase (COX) as a mod...

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Veröffentlicht in:	Genome biology and evolution 2014-11, Vol.6 (11), p.3064-3076
Hauptverfasser:	Aledo, Juan Carlos, Valverde, Héctor, Ruíz-Camacho, Manuel, Morilla, Ian, López, Francisco Demetrio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Cattle DNA, Mitochondrial - genetics Electron Transport Complex IV - chemistry Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Evolution, Molecular Molecular Sequence Data Protein Binding Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Selection, Genetic
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