Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer

Tumor contains small population of cancer stem cells (CSC) that are responsible for its maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and therapeutic strategies for the treatment of cancer patients. We report here the identification of CSCs from human lung cancer c...

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Veröffentlicht in:	Molecular cancer research 2009-03, Vol.7 (3), p.330-338
Hauptverfasser:	Jiang, Feng, Qiu, Qi, Khanna, Abha, Todd, Nevins W, Deepak, Janaki, Xing, Lingxiao, Wang, Huijun, Liu, Zhenqiu, Su, Yun, Stass, Sanford A, Katz, Ruth L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - biosynthesis Aldehyde Dehydrogenase - metabolism Aldehyde Dehydrogenase 1 Family ALDH1 Animals Antineoplastic Agents - pharmacology Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Cell Growth Processes - physiology Cell Line, Tumor Drug Screening Assays, Antitumor Female Flow Cytometry Humans Isoenzymes - biosynthesis Isoenzymes - metabolism lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - pathology Male marker Mice Mice, Nude Middle Aged Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - pathology Prognosis Retinal Dehydrogenase stem cell Transplantation, Heterologous
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