Role of Suspended Fiber Structural Stiffness and Curvature on Single-Cell Migration, Nucleus Shape, and Focal-Adhesion-Cluster Length

It has been shown that cellular migration, persistence, and associated cytoskeletal arrangement are highly dependent on substrate stiffness (modulus: N/m2 and independent of geometry), but little is known on how cells respond to subtle changes in local geometry and structural stiffness (N/m). Here,...

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Veröffentlicht in:	Biophysical journal 2014-12, Vol.107 (11), p.2604-2611
Hauptverfasser:	Meehan, Sean, Nain, Amrinder S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysics Cell adhesion & migration Cell Biophysics Cell Line Cell Movement Cell Nucleus Shape Cellular biology Cytoskeleton Cytoskeleton - metabolism Focal Adhesions - metabolism Geometry Mice Mutation Physiology
Online-Zugang:	Volltext
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