Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide

Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca2+ concentration ([Ca2+]c) and insulin secretion in mouse islets. Alone...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2014-09, Vol.155 (9), p.3274-3287
Hauptverfasser:	Henquin, Jean-Claude, Nenquin, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Calcium - metabolism Calcium ions Cyclic AMP Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Cytosol - metabolism Diabetes-Insulin-Glucagon-Gastrointestinal Enzyme Activators - pharmacology Exocytosis Female Glucose Glucose - metabolism Guanine Nucleotide Exchange Factors - agonists Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinases Mice Mice, Inbred C57BL Potassium chloride Protein kinase A Proteins Signal Transduction - drug effects Stimulation Tolbutamide Tolbutamide - pharmacology
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