Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 expression by macrophages as the critical mediator of this phenotype. Infiltrating macrophages were the primary source of...

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Veröffentlicht in:	Cancer cell 2014-11, Vol.26 (5), p.623-637
Hauptverfasser:	Ruffell, Brian, Chang-Strachan, Debbie, Chan, Vivien, Rosenbusch, Alexander, Ho, Christine M.T., Pryer, Nancy, Daniel, Dylan, Hwang, E. Shelley, Rugo, Hope S., Coussens, Lisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Antineoplastic Agents, Phytogenic - pharmacology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Dendritic Cells - metabolism Female Humans Integrin alpha Chains Interleukin-10 - physiology Interleukin-12 Subunit p35 - biosynthesis Interleukin-12 Subunit p35 - genetics Macrophages Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - metabolism Mice, Transgenic Paclitaxel - pharmacology Receptors, Interleukin-10 - antagonists & inhibitors Receptors, Interleukin-10 - metabolism
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