RAD51AP1-deficiency in vertebrate cells impairs DNA replication

•We report on the phenotype of RAD51AP1-deficient DT40 cells.•RAD51AP1 is required for the resolution of DNA damage-induced RAD51 foci.•RAD51AP1 is required for the maintenance of DNA replication fork progression.•RAD51AP1-deficient DT40 cells show increased firing of dormant replication origins.•RA...

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Veröffentlicht in:	DNA repair 2014-12, Vol.24, p.87-97
Hauptverfasser:	Parplys, Ann C., Kratz, Katja, Speed, Michael C., Leung, Stanley G., Schild, David, Wiese, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line - drug effects Cell Line - radiation effects Chickens Cisplatin - pharmacology DNA Damage - drug effects DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DT40 cells Gene Knockout Techniques Genetic Complementation Test Homologous recombination Humans Hydroxyurea - pharmacology Molecular Sequence Data RAD51 foci Rad51 Recombinase - genetics Rad51 Recombinase - metabolism RAD51AP1 Radiation, Ionizing Vertebrates - genetics
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