Reactive oxygen species and the bacterial response to lethal stress
Highlights • Lethal antimicrobial stress triggers accumulation of reactive oxygen species (ROS). • The stress-mediated ROS cascade and its effects are controlled in multiple ways. • At moderate levels, ROS reduce stress by inducing protective regulons. • At high levels, ROS can be destructive by cre...
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| Veröffentlicht in: | Current opinion in microbiology 2014-10, Vol.21, p.1-6 |
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| creator | Zhao, Xilin Drlica, Karl |
| description | Highlights • Lethal antimicrobial stress triggers accumulation of reactive oxygen species (ROS). • The stress-mediated ROS cascade and its effects are controlled in multiple ways. • At moderate levels, ROS reduce stress by inducing protective regulons. • At high levels, ROS can be destructive by creating a variety of secondary lesions. • Dietary consumption of antioxidants may antagonize antimicrobial therapy. |
| doi_str_mv | 10.1016/j.mib.2014.06.008 |
| format | Article |
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Drlica, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-1b09daaef5357a8d1027e1edb6fa67a633670f1a01407da972d56f0af3f29bc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteria</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - metabolism</topic><topic>Models, Theoretical</topic><topic>Oxidative Stress</topic><topic>Pathology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Xilin</creatorcontrib><creatorcontrib>Drlica, Karl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xilin</au><au>Drlica, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactive oxygen species and the bacterial response to lethal stress</atitle><jtitle>Current opinion in microbiology</jtitle><addtitle>Curr Opin Microbiol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>21</volume><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1369-5274</issn><eissn>1879-0364</eissn><abstract>Highlights • Lethal antimicrobial stress triggers accumulation of reactive oxygen species (ROS). • The stress-mediated ROS cascade and its effects are controlled in multiple ways. • At moderate levels, ROS reduce stress by inducing protective regulons. • At high levels, ROS can be destructive by creating a variety of secondary lesions. • Dietary consumption of antioxidants may antagonize antimicrobial therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25078317</pmid><doi>10.1016/j.mib.2014.06.008</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current opinion in microbiology, 2014-10, Vol.21, p.1-6 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anti-Bacterial Agents - pharmacology Bacteria Bacteria - drug effects Bacteria - metabolism Models, Theoretical Oxidative Stress Pathology Reactive Oxygen Species - metabolism Signal Transduction - drug effects |
| title | Reactive oxygen species and the bacterial response to lethal stress |
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