Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

Histone H2B ubiquitination is a dynamic modification that promotes methylation of histone H3K79 and H3K4. This crosstalk is important for the DNA damage response and has been implicated in cancer. Here, we show that in engineered yeast strains, ubiquitins tethered to every nucleosome promote H3K79 a...

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Veröffentlicht in:	EMBO reports 2014-10, Vol.15 (10), p.1077-1084
Hauptverfasser:	Vlaming, Hanneke, van Welsem, Tibor, de Graaf, Erik L, Ontoso, David, Altelaar, AF Maarten, San-Segundo, Pedro A, Heck, Albert JR, van Leeuwen, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioengineering chromatin Chromatin - genetics Chromatin - metabolism crosstalk Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA methylation DNA repair Dot1 EMBO09 EMBO31 histone ubiquitination Histone-Lysine N-Methyltransferase - metabolism Histones - genetics Histones - metabolism Irradiation Methylation Nucleosomes - genetics Nucleosomes - metabolism Plasticity Saccharomyces cerevisiae Scientific Report Scientific Reports Set1 Ubiquitination - genetics Ubiquitins - genetics Ubiquitins - metabolism Ultraviolet radiation Yeast Yeasts
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