Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions

Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known as GC1008, is a pan‐TGFβ neutralizing antibody that has been tested clinically for several indications including an ongoing trial for focal...

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Veröffentlicht in:	Protein science 2014-12, Vol.23 (12), p.1698-1707
Hauptverfasser:	Moulin, Aaron, Mathieu, Magali, Lawrence, Catherine, Bigelow, Russell, Levine, Mark, Hamel, Christine, Marquette, Jean‐Piere, Parc, Josiane, Loux, Christophe, Ferrari, Paul, Capdevila, Cecile, Dumas, Jacques, Dumas, Bruno, Rak, Alexey, Bird, Julie, Qiu, Huawei, Pan, Clark Q., Edmunds, Tim, Wei, Ronnie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology antibody Antibody Specificity - immunology Antigen-Antibody Reactions - immunology Antigens Crystal structure Crystallography, X-Ray Fab fibrosis Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Isoforms ligand Models, Molecular pan‐specific inhibitor protein complex Protein Conformation Protein Isoforms - chemistry Protein Isoforms - immunology receptor Single-Chain Antibodies - chemistry Single-Chain Antibodies - immunology transforming growth factor beta Transforming Growth Factor beta - chemistry Transforming Growth Factor beta - immunology Transforming growth factor-b1 X‐ray crystallography
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