DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA

The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in sensing DNA damage, as well as in resecting and tethering DNA ends, and thus participates in double‐strand break repair. An earlier structure of Mre11 bound to a short duplex DNA molecule suggested that each Mre11 in a dimer recognizes one...

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Veröffentlicht in:	The EMBO journal 2014-10, Vol.33 (20), p.2422-2435
Hauptverfasser:	Sung, Sihyun, Li, Fuyang, Park, Young Bong, Kim, Jin Seok, Kim, Ae-Kyoung, Song, Ok-kyu, Kim, Jiae, Che, Jun, Lee, Sang Eun, Cho, Yunje
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Archaeal Proteins - chemistry Archaeal Proteins - genetics Archaeal Proteins - metabolism Biochemistry conserved basic region Crystal structure Crystallography, X-Ray Deoxyribonucleic acid Dimerization DNA DNA Breaks, Double-Stranded DNA end recognition DNA End-Joining Repair DNA Mutational Analysis DNA repair DNA, Archaeal - genetics DNA, Archaeal - metabolism DSB repair EMBO13 EMBO40 Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Enzymes Exodeoxyribonucleases - chemistry Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Melting Methanocaldococcus - chemistry Methanocaldococcus - enzymology Methanocaldococcus - genetics Models, Molecular Models, Structural Molecular biology Molecular Sequence Data Mre11-DNA Protein Binding Sequence Alignment
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