Endogenous interleukin‐6 amplifies interleukin‐17 production and corticoid‐resistance in peripheral T cells from patients with multiple sclerosis

Summary Interleukin‐6 (IL‐6) has been implicated in the induction of pathogenic IL‐17‐producing T cells in autoimmune diseases, and studies evaluating the role of this cytokine in T‐cell function in patients with multiple sclerosis (MS) are lacking. Our objective was to evaluate the role of IL‐6 rec...

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Veröffentlicht in:	Immunology 2014-12, Vol.143 (4), p.560-568
Hauptverfasser:	Ferreira, Thais B., Hygino, Joana, Barros, Priscila O., Teixeira, Bruna, Kasahara, Taissa M., Linhares, Ulisses C., Lopes, Lana Márcia F., Vasconcelos, Claudia Cristina F., Alvarenga, Regina, Wing, Ana Cristina, Andrade, Regis M., Andrade, Arnaldo F. B., Bento, Cleonice A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - metabolism Adrenal Cortex Hormones - pharmacology Adult Cell growth cytokines Cytokines - biosynthesis Drug Resistance Female Humans Interleukin-17 - biosynthesis Interleukin-6 - metabolism interleukin‐10 interleukin‐17 interleukin‐6 Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes Male Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - metabolism Original Receptors, Interleukin-6 - metabolism Signal Transduction T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th17 Cells - immunology Th17 Cells - metabolism Young Adult
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