Glycogen synthase kinase-3β inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth

Cancer cells with stem or progenitor properties play a pivotal role in the initiation, recurrence and metastatic potential of solid tumors, including those of the human prostate. Cancer stem cells are generally more resistant to conventional therapies thus requiring the characterization of key pathw...

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Veröffentlicht in:	Oncotarget 2014-10, Vol.5 (19), p.8986-8994
Hauptverfasser:	Kroon, Jan, in 't Veld, Lars S, Buijs, Jeroen T, Cheung, Henry, van der Horst, Geertje, van der Pluijm, Gabri
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cell Line, Tumor Cell Movement Cell Proliferation - drug effects Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta Humans Integrin alpha2beta1 - biosynthesis Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis - pathology Neoplastic Stem Cells - cytology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Protein Kinase Inhibitors - pharmacology Protein Multimerization - drug effects Research Paper Wnt Proteins - antagonists & inhibitors Wnt Signaling Pathway - drug effects
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