Bile salt stimulation of colonic epithelial proliferation: evidence for involvement of lipoxygenase products

Prostaglandin E2 (PGE2) and several other prostaglandins synthesized by colon suppress the proliferative activity of colonic epithelium. However, bile salts stimulate colonic epithelial proliferation despite the actions of bile salts to enhance the release of arachidonate and consequent colonic synt...

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Veröffentlicht in:	The Journal of clinical investigation 1984-11, Vol.74 (5), p.1614-1624
Hauptverfasser:	DERUBERTIS, F. R, CRAVEN, P. A, SAITO, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid Arachidonic Acids - metabolism Bile Acids and Salts - pharmacology Bile Acids and Salts - physiology Biological and medical sciences Colon - cytology Dinoprostone DNA - biosynthesis Epithelium - physiology Female Fundamental and applied biological sciences. Psychology Hydroxyeicosatetraenoic Acids - physiology Indomethacin - pharmacology Intestine. Mesentery Lipoxygenase - physiology Ornithine Decarboxylase - biosynthesis Prostaglandins E - biosynthesis Pyrazoles - pharmacology Rats Rats, Inbred Strains Thromboxane B2 - metabolism Vertebrates: digestive system
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