A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic neurodegenerative tauopathies. Recent in vitro and in vivo studies have shown that tau aggregates do not only seed further...

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Veröffentlicht in:	Acta neuropathologica 2014-05, Vol.127 (5), p.667-683
Hauptverfasser:	Ahmed, Zeshan, Cooper, Jane, Murray, Tracey K., Garn, Katya, McNaughton, Emily, Clarke, Hannah, Parhizkar, Samira, Ward, Mark A., Cavallini, Annalisa, Jackson, Samuel, Bose, Suchira, Clavaguera, Florence, Tolnay, Markus, Lavenir, Isabelle, Goedert, Michel, Hutton, Michael L., O’Neill, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Analysis Animals Brain Brain - metabolism Brain - pathology Disease Disease Models, Animal Disease Progression Female Genetic engineering Hippocampus - metabolism Hippocampus - pathology Humans Immunohistochemistry Medicine Medicine & Public Health Mice, Inbred C57BL Mice, Transgenic Neural Pathways - metabolism Neural Pathways - pathology Neurodegeneration Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurosciences Original Paper Pathology Propagation Random Allocation Synapses - metabolism Synapses - pathology tau Proteins - genetics tau Proteins - metabolism Tauopathies - metabolism Tauopathies - pathology Time Factors Transgenic animals White Matter - metabolism White Matter - pathology
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