Genetic variants in Cell Adhesion Molecule 1 ( CADM1 ): A validation study of a novel endothelial cell venous thrombosis risk factor

Abstract Introduction In a protein C deficient family, we recently identified a candidate gene, CADM1 , which interacted with protein C deficiency in increasing the risk of venous thrombosis (VT). This study aimed to determine whether CADM1 variants also interact with protein C pathway abnormalities...

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Veröffentlicht in:	Thrombosis research 2014-12, Vol.134 (6), p.1186-1192
Hauptverfasser:	de Haan, Hugoline G, Bezemer, Irene D, Vossen, Carla Y, van Hylckama Vlieg, Astrid, Böehringer, Stefan, Hasstedt, Sandra J, Levy, Samuel, Rosendaal, Frits R, Bovill, Edwin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged CADM1 Cell Adhesion Molecule-1 Cell Adhesion Molecules - genetics Comorbidity Endothelial Cells - metabolism Female Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics genetic variation Genetic Variation - genetics Hematology, Oncology and Palliative Medicine Humans Immunoglobulins - genetics Incidence Male Middle Aged Netherlands - epidemiology Polymorphism, Single Nucleotide - genetics Protein C - analysis Protein C - genetics Protein C Deficiency - blood Protein C Deficiency - epidemiology Protein C Deficiency - genetics protein C pathway Reproducibility of Results Risk Factors Sensitivity and Specificity venous thrombosis Venous Thrombosis - epidemiology Venous Thrombosis - genetics Young Adult
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