Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
Gene–environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2014-11, Vol.104 (5), p.376-382 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Irier, Hasan Street, R. Craig Dave, Ronak Lin, Li Cai, Catherine Davis, Timothy Hayden Yao, Bing Cheng, Ying Jin, Peng |
| description | Gene–environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene–environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In particular, genes involved in axon guidance are enriched among the genes with altered 5hmC modification. These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals. |
| doi_str_mv | 10.1016/j.ygeno.2014.08.019 |
| format | Article |
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Craig ; Dave, Ronak ; Lin, Li ; Cai, Catherine ; Davis, Timothy Hayden ; Yao, Bing ; Cheng, Ying ; Jin, Peng</creator><creatorcontrib>Irier, Hasan ; Street, R. Craig ; Dave, Ronak ; Lin, Li ; Cai, Catherine ; Davis, Timothy Hayden ; Yao, Bing ; Cheng, Ying ; Jin, Peng</creatorcontrib><description>Gene–environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene–environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In particular, genes involved in axon guidance are enriched among the genes with altered 5hmC modification. These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/j.ygeno.2014.08.019</identifier><identifier>PMID: 25205305</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>5-Methylcytosine - metabolism ; 5hmC ; Aging ; Animals ; Axon guidance ; cytosine ; Cytosine - analogs & derivatives ; Cytosine - metabolism ; DNA ; DNA Methylation ; Enriched environment ; environmental enrichment ; Epigenetics ; Gene Expression Regulation ; Gene-Environment Interaction ; genes ; hippocampus ; Hippocampus - metabolism ; Learning ; memory ; Mice</subject><ispartof>Genomics (San Diego, Calif.), 2014-11, Vol.104 (5), p.376-382</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>2014 Elsevier Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-60b7f51a86a0cf292fd13126c236dc69326adaa95aca0fc0362cd7c54a8f26f83</citedby><cites>FETCH-LOGICAL-c595t-60b7f51a86a0cf292fd13126c236dc69326adaa95aca0fc0362cd7c54a8f26f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S088875431400161X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25205305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irier, Hasan</creatorcontrib><creatorcontrib>Street, R. 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These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals.</description><subject>5-Methylcytosine - metabolism</subject><subject>5hmC</subject><subject>Aging</subject><subject>Animals</subject><subject>Axon guidance</subject><subject>cytosine</subject><subject>Cytosine - analogs & derivatives</subject><subject>Cytosine - metabolism</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Enriched environment</subject><subject>environmental enrichment</subject><subject>Epigenetics</subject><subject>Gene Expression Regulation</subject><subject>Gene-Environment Interaction</subject><subject>genes</subject><subject>hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Learning</subject><subject>memory</subject><subject>Mice</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGL1TAQhYMo7t3VXyBIH31pnSRNmjwoyLKuwoIg-hyySbrNpU1q0l7svzfXuy76oj6FId-cmTkHoRcYGgyYv943250LsSGA2wZEA1g-QjsMQtaCt_wx2oEQou5YS8_Qec57AJBUkKfojDACjALboc9X4eBTDJMLix4rF5I3w7GopmjXUS8uV6weNpvi921yy7CNZlti9sFVdgt68iZXPlSDn-do9DSv-Rl60usxu-f37wX6-v7qy-WH-ubT9cfLdze1YZItNYfbrmdYC67B9ESS3mKKCTeEcmu4pIRrq7Vk2mjoDVBOjO0Ma7XoCe8FvUBvT7rzejs5a8rSSY9qTn7SaVNRe_XnT_CDuosH1ZbzO8GLwKt7gRS_rS4vavLZuHHUwcU1K1IMw0wWp_6JYt52AKIl8j9QIiUHJruC0hNqUsw5uf5heQzqmLHaq58Zq2PGCoQqGZeul7_f_dDzK9QCvDkBrrh_8C6pbLwLxlmfnFmUjf6vA34AB2-7vA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Irier, Hasan</creator><creator>Street, R. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 5-Methylcytosine - metabolism 5hmC Aging Animals Axon guidance cytosine Cytosine - analogs & derivatives Cytosine - metabolism DNA DNA Methylation Enriched environment environmental enrichment Epigenetics Gene Expression Regulation Gene-Environment Interaction genes hippocampus Hippocampus - metabolism Learning memory Mice |
| title | Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus |
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