RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis

Abstract Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL...

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Veröffentlicht in:	Journal of neuroimmunology 2014-11, Vol.276 (1), p.142-149
Hauptverfasser:	Martinez, Nicholas E, Sato, Fumitaka, Omura, Seiichi, Kawai, Eiichiro, Takahashi, Satoru, Yoh, Keigyou, Tsunoda, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autoimmune disease Cell Proliferation - drug effects Cell Proliferation - genetics Central Nervous System - metabolism Central Nervous System - pathology Demyelinating disease Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - genetics Flow Cytometry Gain-of-function Genetic association Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Multiple Sclerosis - chemically induced Multiple Sclerosis - genetics Multiple Sclerosis - pathology Neurology Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics T cell differentiation T-Box Domain Proteins - genetics Th1 Cells - pathology
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