Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection

Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection

Purpose To study the dependence of apparent diffusion coefficient (ADC) and T2 on echo time (TE) and b‐value, respectively, in normal prostate and prostate cancer, using two‐dimensional MRI sampling, referred to as “hybrid multidimensional imaging.” Materials and Methods The study included 10 patien...

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Veröffentlicht in:Journal of magnetic resonance imaging 2014-04, Vol.39 (4), p.781-788
Hauptverfasser: Wang, Shiyang, Peng, Yahui, Medved, Milica, Yousuf, Ambereen N., Ivancevic, Marko K., Karademir, Ibrahim, Jiang, Yulei, Antic, Tatjana, Sammet, Steffen, Oto, Aytekin, Karczmar, Gregory S.
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ADC
DWI
Magnetic resonance imaging
multidimensional hybrid MRI
prostate cancer
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container_end_page 788
container_issue 4
container_start_page 781
container_title Journal of magnetic resonance imaging
container_volume 39
creator Wang, Shiyang
Peng, Yahui
Medved, Milica
Yousuf, Ambereen N.
Ivancevic, Marko K.
Karademir, Ibrahim
Jiang, Yulei
Antic, Tatjana
Sammet, Steffen
Oto, Aytekin
Karczmar, Gregory S.
description Purpose To study the dependence of apparent diffusion coefficient (ADC) and T2 on echo time (TE) and b‐value, respectively, in normal prostate and prostate cancer, using two‐dimensional MRI sampling, referred to as “hybrid multidimensional imaging.” Materials and Methods The study included 10 patients with biopsy‐proven prostate cancer who underwent 3 Tesla prostate MRI. Diffusion‐weighted MRI (DWI) data were acquired at b = 0, 750, and 1500 s/mm2. For each b‐value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T2 were measured as a function of b‐value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T2 as a function of b‐value. Results In normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (P = 0.0003) and T2 at b‐value of 0 s/mm2 is significantly longer than T2 at b‐value of 1500 s/mm2 (P = 0.001). In cancer ROIs, average ADC and T2 values do not change as a function of TE and b‐value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T2 as a function of b‐value. Cancers are more conspicuous in ADC maps at longer TEs. Conclusion Parameters derived from hybrid imaging that depend on coupled/associated values of ADC and T2 may improve the accuracy of MRI in diagnosing prostate cancer. J. Magn. Reson. Imaging 2014;39:781–788. © 2013 Wiley Periodicals, Inc.
doi_str_mv 10.1002/jmri.24212
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Diffusion‐weighted MRI (DWI) data were acquired at b = 0, 750, and 1500 s/mm2. For each b‐value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T2 were measured as a function of b‐value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T2 as a function of b‐value. Results In normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (P = 0.0003) and T2 at b‐value of 0 s/mm2 is significantly longer than T2 at b‐value of 1500 s/mm2 (P = 0.001). In cancer ROIs, average ADC and T2 values do not change as a function of TE and b‐value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T2 as a function of b‐value. Cancers are more conspicuous in ADC maps at longer TEs. Conclusion Parameters derived from hybrid imaging that depend on coupled/associated values of ADC and T2 may improve the accuracy of MRI in diagnosing prostate cancer. J. Magn. Reson. Imaging 2014;39:781–788. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24212</identifier><identifier>PMID: 23908146</identifier><language>eng</language><publisher>Nashville: Blackwell Publishing Ltd</publisher><subject>ADC ; DWI ; Magnetic resonance imaging ; multidimensional hybrid MRI ; prostate cancer</subject><ispartof>Journal of magnetic resonance imaging, 2014-04, Vol.39 (4), p.781-788</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2013 Wiley Periodicals, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,1434,27926,27927,45576,45577,46411,46835</link.rule.ids></links><search><creatorcontrib>Wang, Shiyang</creatorcontrib><creatorcontrib>Peng, Yahui</creatorcontrib><creatorcontrib>Medved, Milica</creatorcontrib><creatorcontrib>Yousuf, Ambereen N.</creatorcontrib><creatorcontrib>Ivancevic, Marko K.</creatorcontrib><creatorcontrib>Karademir, Ibrahim</creatorcontrib><creatorcontrib>Jiang, Yulei</creatorcontrib><creatorcontrib>Antic, Tatjana</creatorcontrib><creatorcontrib>Sammet, Steffen</creatorcontrib><creatorcontrib>Oto, Aytekin</creatorcontrib><creatorcontrib>Karczmar, Gregory S.</creatorcontrib><title>Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose To study the dependence of apparent diffusion coefficient (ADC) and T2 on echo time (TE) and b‐value, respectively, in normal prostate and prostate cancer, using two‐dimensional MRI sampling, referred to as “hybrid multidimensional imaging.” Materials and Methods The study included 10 patients with biopsy‐proven prostate cancer who underwent 3 Tesla prostate MRI. Diffusion‐weighted MRI (DWI) data were acquired at b = 0, 750, and 1500 s/mm2. For each b‐value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T2 were measured as a function of b‐value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T2 as a function of b‐value. Results In normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (P = 0.0003) and T2 at b‐value of 0 s/mm2 is significantly longer than T2 at b‐value of 1500 s/mm2 (P = 0.001). In cancer ROIs, average ADC and T2 values do not change as a function of TE and b‐value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T2 as a function of b‐value. Cancers are more conspicuous in ADC maps at longer TEs. Conclusion Parameters derived from hybrid imaging that depend on coupled/associated values of ADC and T2 may improve the accuracy of MRI in diagnosing prostate cancer. J. Magn. Reson. Imaging 2014;39:781–788. © 2013 Wiley Periodicals, Inc.</description><subject>ADC</subject><subject>DWI</subject><subject>Magnetic resonance imaging</subject><subject>multidimensional hybrid MRI</subject><subject>prostate cancer</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVkFtLAzEQhYMoVqsv_oKAz6u57uVFUPFSaStoRehLyCazmrqXms2q_fdurQg-zTBzzsfMQeiIkhNKCDtdVN6dMMEo20J7VDIWMZnG231PJI9oSpIB2m_bBSEky4TcRQPGM5JSEe-hx9tV7p3FVVcGZ10FdeuaWpd4xrCuLbauKLr1KPoE9_IawOLJwwgXjcdL37RBB8BG1wY8thDAhF56gHYKXbZw-FuH6On6anZ5G43vb0aX5-PIcSlYlDJjDeVxDpYJamNh-psyYqnJuTSEEU6MBZ1onUqecVrEAEUmKDdM51IQPkRnG-6yyyuwBurgdamW3lXar1Sjnfq_qd2remk-lGCSJlnaA45_Ab5576ANatF0vv--VVSSNGYySUWvohvVpyth9YenRK3TV-v01U_66q6P5qfrPdHG49oAX38e7d9UnPBEqufpjRrPLybTeTJVCf8GSNCJKw</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Wang, Shiyang</creator><creator>Peng, Yahui</creator><creator>Medved, Milica</creator><creator>Yousuf, Ambereen N.</creator><creator>Ivancevic, Marko K.</creator><creator>Karademir, Ibrahim</creator><creator>Jiang, Yulei</creator><creator>Antic, Tatjana</creator><creator>Sammet, Steffen</creator><creator>Oto, Aytekin</creator><creator>Karczmar, Gregory S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201404</creationdate><title>Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection</title><author>Wang, Shiyang ; Peng, Yahui ; Medved, Milica ; Yousuf, Ambereen N. ; Ivancevic, Marko K. ; Karademir, Ibrahim ; Jiang, Yulei ; Antic, Tatjana ; Sammet, Steffen ; Oto, Aytekin ; Karczmar, Gregory S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3542-82cdc136bed241d64c08190d1cb35c02030cdea7aa853931f6eef9413c2ab5403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ADC</topic><topic>DWI</topic><topic>Magnetic resonance imaging</topic><topic>multidimensional hybrid MRI</topic><topic>prostate cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shiyang</creatorcontrib><creatorcontrib>Peng, Yahui</creatorcontrib><creatorcontrib>Medved, Milica</creatorcontrib><creatorcontrib>Yousuf, Ambereen N.</creatorcontrib><creatorcontrib>Ivancevic, Marko K.</creatorcontrib><creatorcontrib>Karademir, Ibrahim</creatorcontrib><creatorcontrib>Jiang, Yulei</creatorcontrib><creatorcontrib>Antic, Tatjana</creatorcontrib><creatorcontrib>Sammet, Steffen</creatorcontrib><creatorcontrib>Oto, Aytekin</creatorcontrib><creatorcontrib>Karczmar, Gregory S.</creatorcontrib><collection>Istex</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shiyang</au><au>Peng, Yahui</au><au>Medved, Milica</au><au>Yousuf, Ambereen N.</au><au>Ivancevic, Marko K.</au><au>Karademir, Ibrahim</au><au>Jiang, Yulei</au><au>Antic, Tatjana</au><au>Sammet, Steffen</au><au>Oto, Aytekin</au><au>Karczmar, Gregory S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2014-04</date><risdate>2014</risdate><volume>39</volume><issue>4</issue><spage>781</spage><epage>788</epage><pages>781-788</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose To study the dependence of apparent diffusion coefficient (ADC) and T2 on echo time (TE) and b‐value, respectively, in normal prostate and prostate cancer, using two‐dimensional MRI sampling, referred to as “hybrid multidimensional imaging.” Materials and Methods The study included 10 patients with biopsy‐proven prostate cancer who underwent 3 Tesla prostate MRI. Diffusion‐weighted MRI (DWI) data were acquired at b = 0, 750, and 1500 s/mm2. For each b‐value, data were acquired at TEs of 47, 75, and 100 ms. ADC and T2 were measured as a function of b‐value and TE, respectively, in 15 cancer and 10 normal regions of interest (ROIs). The Friedman test was used to test the significance of changes in ADC as a function of TE and of T2 as a function of b‐value. Results In normal prostate ROIs, the ADC at TE of 47 ms is significantly smaller than ADC at TE of 100 ms (P = 0.0003) and T2 at b‐value of 0 s/mm2 is significantly longer than T2 at b‐value of 1500 s/mm2 (P = 0.001). In cancer ROIs, average ADC and T2 values do not change as a function of TE and b‐value, respectively. However, in many cancer pixels, there are large decreases in the ADC as a function of TE and large increases in T2 as a function of b‐value. Cancers are more conspicuous in ADC maps at longer TEs. Conclusion Parameters derived from hybrid imaging that depend on coupled/associated values of ADC and T2 may improve the accuracy of MRI in diagnosing prostate cancer. J. Magn. Reson. Imaging 2014;39:781–788. © 2013 Wiley Periodicals, Inc.</abstract><cop>Nashville</cop><pub>Blackwell Publishing Ltd</pub><pmid>23908146</pmid><doi>10.1002/jmri.24212</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects ADC
DWI
Magnetic resonance imaging
multidimensional hybrid MRI
prostate cancer
title Hybrid multidimensional T2 and diffusion-weighted MRI for prostate cancer detection
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