Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice
To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones un...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-02, Vol.11 (5), p.737-740 |
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| creator | Cao, Shu-Guang Wu, Wan-Chun Han, Zhen Wang, Meng-Ya |
| description | To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones under psychological stress.
Thirty-six mice were randomly divided into psychological stress group and control group. A mouse model with psychological stress was established by housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA).
Small intestinal transit was inhibited (52.18+/-19.15% vs 70.19+/-17.79%, P |
| doi_str_mv | 10.3748/wjg.v11.i5.737 |
| format | Article |
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Thirty-six mice were randomly divided into psychological stress group and control group. A mouse model with psychological stress was established by housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA).
Small intestinal transit was inhibited (52.18+/-19.15% vs 70.19+/-17.79%, P<0.01) in mice after psychological stress, compared to the controls. Small intestinal CCK levels in psychological stress mice were significantly lower than those in the control group (0.75+/-0.53 microg/g vs 1.98+/-1.17 microg/g, P<0.01), whereas plasma CCK concentrations were not different between the groups. VIP levels in small intestine were significantly higher in psychological stress mice than those in the control group (8.45+/-1.09 microg/g vs 7.03+/-2.36 microg/g, P<0.01), while there was no significant difference in plasma VIP levels between the two groups.
Psychological stress inhibits the small intestinal transit, probably by down-regulating CCK and up-regulating VIP expression in small intestine.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i5.737</identifier><identifier>PMID: 15655834</identifier><language>eng</language><publisher>United States: Department of Gastroenterology, Yijishan Hospital, Wuhu 241001, Anhui Province, China%Department of Physiology, Wannan Medical College,Wuhu 241001, Anhui Province, China</publisher><subject>Animals ; Brief Reports ; Cats ; Cholecystokinin - blood ; Down-Regulation ; Fear - physiology ; Gastrointestinal Motility - physiology ; Intestine, Small - metabolism ; Intestine, Small - physiopathology ; Male ; Mice ; Stress, Psychological - blood ; Stress, Psychological - physiopathology ; Up-Regulation ; Vasoactive Intestinal Peptide - blood</subject><ispartof>World journal of gastroenterology : WJG, 2005-02, Vol.11 (5), p.737-740</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-2ed3844395879a93a797ad302202198c93660b96add0d257218c13a9f9cdef6b3</citedby><cites>FETCH-LOGICAL-c483t-2ed3844395879a93a797ad302202198c93660b96add0d257218c13a9f9cdef6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250751/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250751/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15655834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Shu-Guang</creatorcontrib><creatorcontrib>Wu, Wan-Chun</creatorcontrib><creatorcontrib>Han, Zhen</creatorcontrib><creatorcontrib>Wang, Meng-Ya</creatorcontrib><title>Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones under psychological stress.
Thirty-six mice were randomly divided into psychological stress group and control group. A mouse model with psychological stress was established by housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA).
Small intestinal transit was inhibited (52.18+/-19.15% vs 70.19+/-17.79%, P<0.01) in mice after psychological stress, compared to the controls. Small intestinal CCK levels in psychological stress mice were significantly lower than those in the control group (0.75+/-0.53 microg/g vs 1.98+/-1.17 microg/g, P<0.01), whereas plasma CCK concentrations were not different between the groups. VIP levels in small intestine were significantly higher in psychological stress mice than those in the control group (8.45+/-1.09 microg/g vs 7.03+/-2.36 microg/g, P<0.01), while there was no significant difference in plasma VIP levels between the two groups.
Psychological stress inhibits the small intestinal transit, probably by down-regulating CCK and up-regulating VIP expression in small intestine.</description><subject>Animals</subject><subject>Brief Reports</subject><subject>Cats</subject><subject>Cholecystokinin - blood</subject><subject>Down-Regulation</subject><subject>Fear - physiology</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Intestine, Small - metabolism</subject><subject>Intestine, Small - physiopathology</subject><subject>Male</subject><subject>Mice</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - physiopathology</subject><subject>Up-Regulation</subject><subject>Vasoactive Intestinal Peptide - blood</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkk1v1DAQhi1ERbeFK0eUA-KW1B9xHF-QUFUKUiUu7dmadZytF8cOsXdL_hK_Emd3Ba18sDTzzPt6PIPQe4IrJur26mm7qfaEVJZXgolXaEUpkSVta_warQjGopSMinN0EeMWY8oYp2_QOeEN5y2rV-jPTd8bnWIR-mKMs34MLmysBlfENJmY476IAzhXWJ9MTNbn1BCSdTbNBfiuML_HBbQZzBqLgNFzTOGn9dYfiD3EADrZvXkuMgY3j2ZMtlvCxegg-xz4l36H7GC1eYvOenDRvDvdl-jh68399bfy7sft9-svd6WuW5ZKajrW1jWTvBUSJAMhBXQMU4rz17RasqbBa9lA1-GOckFJqwkD2Uvdmb5Zs0v0-ag77taD6bTxaQKnxskOMM0qgFUvM94-qk3Yq5pyLDjJAh-PAk_ge_AbtQ27KbccVZ4WxZjnQ5uMfTr5TOHXLveqBhu1cQ68CbuomjxQQQjLYHUE9RRinEz_7y0Eq2ULFl2Vt0BZrnJRLvjwvIP_-Gns7C-ZjLSP</recordid><startdate>20050207</startdate><enddate>20050207</enddate><creator>Cao, Shu-Guang</creator><creator>Wu, Wan-Chun</creator><creator>Han, Zhen</creator><creator>Wang, Meng-Ya</creator><general>Department of Gastroenterology, Yijishan Hospital, Wuhu 241001, Anhui Province, China%Department of Physiology, Wannan Medical College,Wuhu 241001, Anhui Province, China</general><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050207</creationdate><title>Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice</title><author>Cao, Shu-Guang ; Wu, Wan-Chun ; Han, Zhen ; Wang, Meng-Ya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-2ed3844395879a93a797ad302202198c93660b96add0d257218c13a9f9cdef6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Brief Reports</topic><topic>Cats</topic><topic>Cholecystokinin - blood</topic><topic>Down-Regulation</topic><topic>Fear - physiology</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Intestine, Small - metabolism</topic><topic>Intestine, Small - physiopathology</topic><topic>Male</topic><topic>Mice</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - physiopathology</topic><topic>Up-Regulation</topic><topic>Vasoactive Intestinal Peptide - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Cao, Shu-Guang</creatorcontrib><creatorcontrib>Wu, Wan-Chun</creatorcontrib><creatorcontrib>Han, Zhen</creatorcontrib><creatorcontrib>Wang, Meng-Ya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Shu-Guang</au><au>Wu, Wan-Chun</au><au>Han, Zhen</au><au>Wang, Meng-Ya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2005-02-07</date><risdate>2005</risdate><volume>11</volume><issue>5</issue><spage>737</spage><epage>740</epage><pages>737-740</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones under psychological stress.
Thirty-six mice were randomly divided into psychological stress group and control group. A mouse model with psychological stress was established by housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA).
Small intestinal transit was inhibited (52.18+/-19.15% vs 70.19+/-17.79%, P<0.01) in mice after psychological stress, compared to the controls. Small intestinal CCK levels in psychological stress mice were significantly lower than those in the control group (0.75+/-0.53 microg/g vs 1.98+/-1.17 microg/g, P<0.01), whereas plasma CCK concentrations were not different between the groups. VIP levels in small intestine were significantly higher in psychological stress mice than those in the control group (8.45+/-1.09 microg/g vs 7.03+/-2.36 microg/g, P<0.01), while there was no significant difference in plasma VIP levels between the two groups.
Psychological stress inhibits the small intestinal transit, probably by down-regulating CCK and up-regulating VIP expression in small intestine.</abstract><cop>United States</cop><pub>Department of Gastroenterology, Yijishan Hospital, Wuhu 241001, Anhui Province, China%Department of Physiology, Wannan Medical College,Wuhu 241001, Anhui Province, China</pub><pmid>15655834</pmid><doi>10.3748/wjg.v11.i5.737</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Brief Reports Cats Cholecystokinin - blood Down-Regulation Fear - physiology Gastrointestinal Motility - physiology Intestine, Small - metabolism Intestine, Small - physiopathology Male Mice Stress, Psychological - blood Stress, Psychological - physiopathology Up-Regulation Vasoactive Intestinal Peptide - blood |
| title | Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice |
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