Effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice

AIM: To study the effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice.METHODS: The membrane fluidity of red cells is measured with DPH fluorescence probe as a marker; the amount of red cell membrane proteins is measured using polyacrylamide gel electrophoresi...

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Veröffentlicht in:World journal of gastroenterology : WJG 2005-02, Vol.11 (6), p.823-830
Hauptverfasser: Ji, Yu-Bin, Gao, Shi-Yong, Cheng, Wei-Ping
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container_title World journal of gastroenterology : WJG
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creator Ji, Yu-Bin
Gao, Shi-Yong
Cheng, Wei-Ping
description AIM: To study the effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice.METHODS: The membrane fluidity of red cells is measured with DPH fluorescence probe as a marker; the amount of red cell membrane proteins is measured using polyacrylamide gel electrophoresis; the amount of sialic acid (SA) on the surface of red cell membrane and the sealability of these cells are measured using colorimetric analysis.RESULTS: Haimiding can lower the membrane fluidity of red cells in tumor-bearing mice and the amount of their membrane proteins, while increasing the amount of sialic acid in the membrane of red cells in these mice and enhancing the ability of the membrane of their red cells to reseal.CONCLUSION: The anti-tumor effect of Haimiding on tumorbearing mice is due to its ability to improve and restore the functions of the membrane of their red cell and to enhance the immune effect of the organisms.
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the amount of red cell membrane proteins is measured using polyacrylamide gel electrophoresis; the amount of sialic acid (SA) on the surface of red cell membrane and the sealability of these cells are measured using colorimetric analysis.RESULTS: Haimiding can lower the membrane fluidity of red cells in tumor-bearing mice and the amount of their membrane proteins, while increasing the amount of sialic acid in the membrane of red cells in these mice and enhancing the ability of the membrane of their red cells to reseal.CONCLUSION: The anti-tumor effect of Haimiding on tumorbearing mice is due to its ability to improve and restore the functions of the membrane of their red cell and to enhance the immune effect of the organisms.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Basic Research</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion - immunology</subject><subject>Erythrocyte Membrane - drug effects</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Female</subject><subject>H22</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Male</subject><subject>Medicine, Chinese Traditional</subject><subject>Membrane Fluidity - drug effects</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>N-Acetylneuraminic Acid - metabolism</subject><subject>Neoplasm Transplantation</subject><subject>活动性</subject><subject>红细胞膜</subject><subject>细胞膜机能</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxUVJSbbbXHssIoTevBl92dalEJakGwj0ktwKQpIlr7a2lMh2Qv_7eLNpaU4DM2_ePH6D0BcCK1bx-uJ5166eCFmFclVT9gEtKCWyoDWHI7QgAFUhGa1O0Kdh2AFQxgQ9RidElDXlFV-gX1feOzvi5PFGhz40IbY4RTxuHfZTtGNI8bXlcXYNtq7rcO96k3V0--b1GuvY4A2leJz6lAvjdN4v9MG6z-ij193gTt_qEt1fX92tN8Xtzx8368vbwlImZGEaK6Q14IUpjfaEMleVjDABzFtDjSRVzZxtzKypKQguLK95Q7XTDeGVZEv0_eD7MJneNdbFMetOPeTQ6_xHJR3U-0kMW9WmJ8WpACFhNjg_GDzr6HVs1S5NOc6R1cyXAggoAfZ3vr3dyelxcsOo-jDskcww0jSosuIAfP7DEn39P9C_JH-5z4Kzg8BuU2wfZ2DKaPvbh84pQqQkQpTsBZfjkCw</recordid><startdate>20050214</startdate><enddate>20050214</enddate><creator>Ji, Yu-Bin</creator><creator>Gao, Shi-Yong</creator><creator>Cheng, Wei-Ping</creator><general>Postdoctoral Research Station, Institute of Materia Medica, Harbin Commercial University,Harbin 150076, Heilongjiang Province, China</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050214</creationdate><title>Effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice</title><author>Ji, Yu-Bin ; 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the amount of red cell membrane proteins is measured using polyacrylamide gel electrophoresis; the amount of sialic acid (SA) on the surface of red cell membrane and the sealability of these cells are measured using colorimetric analysis.RESULTS: Haimiding can lower the membrane fluidity of red cells in tumor-bearing mice and the amount of their membrane proteins, while increasing the amount of sialic acid in the membrane of red cells in these mice and enhancing the ability of the membrane of their red cells to reseal.CONCLUSION: The anti-tumor effect of Haimiding on tumorbearing mice is due to its ability to improve and restore the functions of the membrane of their red cell and to enhance the immune effect of the organisms.</abstract><cop>United States</cop><pub>Postdoctoral Research Station, Institute of Materia Medica, Harbin Commercial University,Harbin 150076, Heilongjiang Province, China</pub><pmid>15682474</pmid><doi>10.3748/wjg.v11.i6.823</doi><tpages>8</tpages></addata></record>
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subjects Animals
Antineoplastic Agents, Phytogenic - pharmacology
Basic Research
Cell Adhesion - drug effects
Cell Adhesion - immunology
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - metabolism
Female
H22
Liver Neoplasms - drug therapy
Male
Medicine, Chinese Traditional
Membrane Fluidity - drug effects
Membrane Proteins - metabolism
Mice
Mice, Inbred Strains
N-Acetylneuraminic Acid - metabolism
Neoplasm Transplantation
活动性
红细胞膜
细胞膜机能
title Effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice
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