Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
Summary The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol...
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| Veröffentlicht in: | Psychoneuroendocrinology 2009-06, Vol.34 (5), p.694-704 |
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| creator | Cunningham-Bussel, Amy C Root, James C Butler, Tracy Tuescher, Oliver Pan, Hong Epstein, Jane Weisholtz, Daniel S Pavony, Michelle Silverman, Michael E Goldstein, Martin S Altemus, Margaret Cloitre, Marylene LeDoux, Joseph McEwen, Bruce Stern, Emily Silbersweig, David |
| description | Summary The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response. |
| doi_str_mv | 10.1016/j.psyneuen.2008.11.011 |
| format | Article |
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Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. 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All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-59220faaa5912c7843278c0dea6b3e3ba88433c0c3ee72b44aaa1a56179f05673</citedby><cites>FETCH-LOGICAL-c585t-59220faaa5912c7843278c0dea6b3e3ba88433c0c3ee72b44aaa1a56179f05673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306453008003193$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21433347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19135805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunningham-Bussel, Amy C</creatorcontrib><creatorcontrib>Root, James C</creatorcontrib><creatorcontrib>Butler, Tracy</creatorcontrib><creatorcontrib>Tuescher, Oliver</creatorcontrib><creatorcontrib>Pan, Hong</creatorcontrib><creatorcontrib>Epstein, Jane</creatorcontrib><creatorcontrib>Weisholtz, Daniel S</creatorcontrib><creatorcontrib>Pavony, Michelle</creatorcontrib><creatorcontrib>Silverman, Michael E</creatorcontrib><creatorcontrib>Goldstein, Martin S</creatorcontrib><creatorcontrib>Altemus, Margaret</creatorcontrib><creatorcontrib>Cloitre, Marylene</creatorcontrib><creatorcontrib>LeDoux, Joseph</creatorcontrib><creatorcontrib>McEwen, Bruce</creatorcontrib><creatorcontrib>Stern, Emily</creatorcontrib><creatorcontrib>Silbersweig, David</creatorcontrib><title>Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Summary The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant levels of cortisol secretion. 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Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response.</description><subject>Adult</subject><subject>Amygdala</subject><subject>Behavior - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping - methods</subject><subject>Circadian Rhythm - physiology</subject><subject>Cortisol</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Frontal Lobe - physiology</subject><subject>Fundamental and applied biological sciences. 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| ispartof | Psychoneuroendocrinology, 2009-06, Vol.34 (5), p.694-704 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Amygdala Behavior - physiology Behavioral psychophysiology Biological and medical sciences Brain Mapping - methods Circadian Rhythm - physiology Cortisol Endocrinology & Metabolism Female Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology Hippocampus Hormones and behavior Humans Hydrocortisone - secretion Limbic System - physiology Magnetic Resonance Imaging Male Medial prefrontal cortex Neuroimaging Photic Stimulation Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time September 11 Terrorist Attacks - psychology Stress Stress, Psychological - metabolism Stress, Psychological - physiopathology |
| title | Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli |
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