Preeclampsia induced by cadmium in rats is related to abnormal local glucocorticoid synthesis in placenta

Cadmium (Cd) is a major environmental pollutant that causes multiple adverse health effects in humans and animals. In this study, we investigated Cd-mediated toxic effects in rats during pregnancy and endocrine intervention in the placenta. We exposed pregnant rats to intraperitoneal Cd (CdCl2) at v...

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Veröffentlicht in:	Reproductive biology and endocrinology 2014-08, Vol.12 (1), p.77-77, Article 77
Hauptverfasser:	Wang, Fan, Zhang, Qiong, Zhang, Xiaojie, Luo, Shunqun, Ye, Duyun, Guo, Yi, Chen, Sisi, Huang, Yinping
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - antagonists & inhibitors 11-beta-Hydroxysteroid Dehydrogenase Type 2 - biosynthesis Analysis Animals Blood pressure Cadmium Cadmium Chloride - administration & dosage Cadmium Chloride - metabolism Cadmium Chloride - pharmacokinetics Cadmium Chloride - toxicity Cadmium Poisoning - blood Cadmium Poisoning - metabolism Cadmium Poisoning - pathology Cadmium Poisoning - physiopathology Corticosterone - blood Corticosterone - metabolism Development and progression Dose-Response Relationship, Drug Environmental Pollutants - administration & dosage Environmental Pollutants - metabolism Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Enzyme Induction - drug effects Enzyme Repression - drug effects Female Gene expression Glucocorticoids - blood Glucocorticoids - metabolism Health aspects Hypertension Hypotheses Injections, Intraperitoneal Obstetrics Placenta Placenta - drug effects Placenta - enzymology Placenta - metabolism Placenta - pathology Pre-Eclampsia - etiology Preeclampsia Pregnancy Pregnancy Complications - blood Pregnancy Complications - metabolism Pregnancy Complications - pathology Pregnancy Complications - physiopathology Proteins Random Allocation Rats, Sprague-Dawley Rodents Science Steroid 11-beta-Hydroxylase - biosynthesis Steroid 21-Hydroxylase - biosynthesis Steroids Studies Tissue Distribution Up-Regulation - drug effects Urine
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