Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells

Burkholderia cenocepacia is notorious for causing respiratory tract infections in people with cystic fibrosis. Infections with this organism are particularly difficult to treat due to its high level of intrinsic resistance to most antibiotics. Multidrug resistance in B. cenocepacia can be ascribed t...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-12, Vol.58 (12), p.7424-7429
Hauptverfasser:	Buroni, Silvia, Matthijs, Nele, Spadaro, Francesca, Van Acker, Heleen, Scoffone, Viola C, Pasca, Maria Rosalia, Riccardi, Giovanna, Coenye, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Base Sequence Biofilms Biofilms - drug effects Biofilms - growth & development Burkholderia Burkholderia cenocepacia Burkholderia cenocepacia - drug effects Burkholderia cenocepacia - genetics Burkholderia cenocepacia - growth & development Ciprofloxacin - pharmacology Drug Resistance, Multiple, Bacterial - genetics Gene Expression Regulation, Bacterial Genes, MDR Mechanisms of Resistance Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbial Sensitivity Tests Molecular Sequence Data Operon Plankton Plankton - drug effects Plankton - genetics Plankton - growth & development RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Deletion Tobramycin - pharmacology
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