Quinacrine inhibits Candida albicans growth and filamentation at neutral pH

Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI), in part due to its strong propensity to form biofilms. Drug repurposing is an approach that might identify agents that are able to overcome antifungal drug resistance within biofilms. Quinacrine (QNC) is clinical...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-12, Vol.58 (12), p.7501-7509
Hauptverfasser:	Kulkarny, Vibhati V, Chavez-Dozal, Alba, Rane, Hallie S, Jahng, Maximillian, Bernardo, Stella M, Parra, Karlett J, Lee, Samuel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B Amphotericin B - pharmacology Antifungal Agents Antifungal Agents - pharmacology Antiprotozoal Agents - pharmacology Biofilms Biofilms - drug effects Biofilms - growth & development Candida Candida albicans Candida albicans - drug effects Candida albicans - growth & development Drug Combinations Drug Repositioning Drug Resistance, Fungal Drug Synergism Echinocandins Echinocandins - pharmacology Endocytosis - drug effects Fluconazole - pharmacology Giardia Hydrogen-Ion Concentration Hyphae - drug effects Hyphae - growth & development Lipopeptides Microbial Sensitivity Tests Microbial Viability - drug effects Plankton - drug effects Plankton - growth & development Plasmodium Quinacrine Quinacrine - pharmacology Susceptibility
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