Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge

The rise in quinolone resistance is threatening the clinical use of this important class of broad-spectrum antibacterials. Quinolones kill bacteria by increasing the level of DNA strand breaks generated by the type II topoisomerases gyrase and topoisomerase IV. Most commonly, resistance is caused by...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-12, Vol.58 (12), p.7182-7187
Hauptverfasser:	Aldred, Katie J, Breland, Erin J, McPherson, Sylvia A, Turnbough, Jr, Charles L, Kerns, Robert J, Osheroff, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Alanine - genetics Anti-Bacterial Agents - chemistry Bacillus anthracis Bacillus anthracis - chemistry Bacillus anthracis - enzymology Cations, Divalent Ciprofloxacin - chemistry DNA Topoisomerase IV DNA Topoisomerase IV - antagonists & inhibitors DNA Topoisomerase IV - chemistry DNA Topoisomerase IV - genetics DNA, Bacterial - chemistry Drug Resistance, Bacterial - genetics Fluoroquinolones - chemistry Manganese Manganese - chemistry Mechanisms of Resistance Models, Molecular Mutation Nickel Nickel - chemistry Protein Subunits Protein Subunits - antagonists & inhibitors Protein Subunits - chemistry Protein Subunits - genetics Recombinant Proteins - chemistry Recombinant Proteins - genetics Topoisomerase Inhibitors - chemistry Valine - chemistry Valine - genetics Water Water - chemistry
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