Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms

Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acte...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2014-11, Vol.58 (11), p.6970-6973
Hauptverfasser:	Hess, Donavon J, Henry-Stanley, Michelle J, Wells, Carol L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Aminoglycosides - pharmacology Ampicillin - pharmacology Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Biofilms Biofilms - drug effects Drug Synergism Drug Therapy, Combination Gentamicins - pharmacology Laurates Laurates - pharmacology Microbial Sensitivity Tests Monoglycerides Monoglycerides - pharmacology Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Streptomycin - pharmacology Surface-Active Agents - pharmacology Susceptibility Vancomycin - pharmacology
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