Enhanced virulence of the Escherichia coli O157:H7 spinach-associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin

Shiga toxin (Stx)-producing Escherichia coli (STEC) causes hemorrhagic colitis and the hemolytic-uremic syndrome (HUS). STEC strains may produce Stx1a and/or Stx2a or variants of either toxin. A 2006 spinach-associated outbreak of STEC O157:H7 resulted in higher hospitalization and HUS rates than pr...

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Veröffentlicht in:	Infection and immunity 2014-12, Vol.82 (12), p.4968-4977
Hauptverfasser:	Zangari, T, Melton-Celsa, A R, Panda, A, Smith, M A, Tatarov, I, De Tolla, L, O'Brien, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - metabolism Bacterial Infections Ciprofloxacin - metabolism Disease Models, Animal Disease Outbreaks Escherichia coli Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Escherichia coli O157 - drug effects Escherichia coli O157 - isolation & purification Escherichia coli O157 - pathogenicity Female Humans Intestines - pathology Male Mice, Inbred BALB C Mice, Inbred ICR Models, Animal Rabbits Shiga Toxin 2 - biosynthesis Spinacia oleracea Spinacia oleracea - microbiology Virulence
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