A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus

H6N6 viruses are commonly isolated from domestic ducks, and avian-to-swine transmissions of H6N6 viruses have been detected in China. Whether subsequent adaptation of H6N6 viruses in mammals would increase their pathogenicity toward humans is not known. To address this, we generated a mouse-adapted...

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Veröffentlicht in:	Journal of virology 2014-12, Vol.88 (24), p.14116-14125
Hauptverfasser:	Tan, Likai, Su, Shuo, Smith, David K, He, Shuyi, Zheng, Yun, Shao, Zhenwen, Ma, Jun, Zhu, Huachen, Zhang, Guihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Biological Animals Body Weight Cell Line Disease Models, Animal Dogs Female Hemagglutinin Glycoproteins, Influenza Virus - genetics Histocytochemistry Humans Influenza A virus Influenza A virus - genetics Influenza A virus - isolation & purification Influenza A virus - pathogenicity Mice, Inbred BALB C Mutant Proteins - genetics Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Pathogenesis and Immunity RNA Replicase - genetics Swine Viral Load Viral Plaque Assay Viral Proteins - genetics Virulence Virulence Factors - genetics Virus Replication
Online-Zugang:	Volltext
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