The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses

Lassa virus is an Old World Arenavirus which causes Lassa hemorrhagic fever in humans, mostly in West Africa. Lassa fever is an important public health problem, and a safe and effective vaccine is urgently needed. The infection causes immunosuppression, probably due to the absence of activation of a...

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Veröffentlicht in:	Journal of virology 2014-12, Vol.88 (23), p.13811-13820
Hauptverfasser:	Russier, Marion, Reynard, Stéphanie, Carnec, Xavier, Baize, Sylvain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Arenavirus Bacteriology Capsid Proteins - genetics Capsid Proteins - immunology Cell Degranulation Cell Survival Cells, Cultured Coculture Techniques Dendritic Cells - immunology Exonucleases - genetics Exonucleases - immunology Humans Immune Tolerance Immunology Interferon-gamma - secretion Interleukins - secretion Killer Cells, Natural - immunology Lassa virus Lassa virus - immunology Life Sciences Macrophages - immunology Microbiology and Parasitology Mutant Proteins - genetics Mutant Proteins - immunology Mutation, Missense Pathogenesis and Immunity Virology
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