Molecular basis for ebolavirus VP35 suppression of human dendritic cell maturation

Zaire ebolavirus (EBOV) VP35 is a double-stranded RNA (dsRNA)-binding protein that inhibits RIG-I signaling and alpha/beta interferon (IFN-α/β) responses by both dsRNA-binding-dependent and -independent mechanisms. VP35 also suppresses dendritic cell (DC) maturation. Here, we define the pathways and...

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Veröffentlicht in:	Journal of virology 2014-11, Vol.88 (21), p.12500-12510
Hauptverfasser:	Yen, Benjamin, Mulder, Lubbertus C F, Martinez, Osvaldo, Basler, Christopher F
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Cells, Cultured DEAD Box Protein 58 DEAD-box RNA Helicases - antagonists & inhibitors Dendritic Cells - physiology Dendritic Cells - virology Ebolavirus - immunology Encephalomyocarditis virus Host-Pathogen Interactions Humans Receptors, Immunologic Sendai virus Signal Transduction Viral Regulatory and Accessory Proteins - metabolism Virus-Cell Interactions
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